2-苯基-1,3-二氧六环-5-醇合成路线 （共 45 条）
反应条件
1,1,3,3-tetramethyldisiloxane; copper(II) bis(trifluoromethanesulfonate) in dichloromethane T=20°C;
参考文献
Zhang, Yin-Jie; Dayoub, Wissam; Chen, Guo-Rong; Lemaire, Marc
Green Chemistry, 2011 , vol. 13, # 10 p. 2737 - 2742
反应条件
1: 2-phenyl-5-hydroxy-1,3-dioxane With sodium hydride in toluene; mineral oil T=20°C; 0.5 h; 2: n-Octadecyl iodide in toluene; mineral oil T=20°C; Inert atmosphereReflux;
参考文献
Huang, Zhaohua; Szoka Jr., Francis C.
Journal of the American Chemical Society, 2008 , vol. 130, # 46 p. 15702 - 15712
参考文献
Wang, Xin; Gao, Feng-Li; Piao, Hong-Bin; Cheng, Tie-Ming; Li, Run-Tao
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 10 p. 1729 - 1732
参考文献
Daubert
Journal of the American Chemical Society, 1940 , vol. 62, p. 1713
反应条件
1: 97 percent / NaH / tetrahydrofuran / 4 h / 55 °C 2: 96 percent / borane-THF complex / 60 h / 20 - 45 °C View Scheme
参考文献
Pinchuk, A. N.; Mitsner, B. I.; Shvets, V. I.
Pharmaceutical Chemistry Journal, 1992 , vol. 26, # 2 p. 174 - 176
Khimiko-Farmatsevticheskii Zhurnal, 1992 , vol. 26, # 2 p. 62 - 64
反应条件
(i) NaH, (ii) /BRN= 969135/, (iii) ion-exchange resin <H+ form>; Multistep reaction;
参考文献
Kertscher; Ostermann
Pharmazie, 1987 , vol. 42, # 11 p. 713 - 715
反应条件
1: pyridine
2: potassium hydroxide / Unter vermindertem Druck
3: palladium/barium sulfate; ethanol / Hydrogenation
View Scheme
参考文献
Fischer et al.
Chemische Berichte, 1931 , vol. 64, p. 611,613
反应条件
sodium hydride in tetrahydrofuran
T=0 - 25°C;
参考文献
Ray III, William C.; Grinstaff, Mark W.
Macromolecules, 2003 , vol. 36, # 10 p. 3557 - 3562
反应条件
in N-methyl-acetamide; water; benzyl bromide; toluene
参考文献
American Cyanamid Company
Patent: US4827011 A1, 1989 ;
反应条件
sodium hydride
1.) toluene, room temp., 15 min, 2.) toluene, reflux, 6 h; Yield given. Multistep reaction;
参考文献
Surles; Wykle; O'Flaherty; Salzer; Thomas; Snyder; Piantadosi
Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 73 - 78
