4-二乙氧基磷苯甲酸乙酯合成路线 （共 10 条）
反应条件
1.1: bromotrimethylsilane / acetonitrile / 3 h / 20 °C 1.2: water / diethyl ether / 0.5 h / 20 °C 2.1: 54 percent Spectr. / Me3NO*2H2O; tetrabutylammonium fluoride / Pd(OAc)2 / tetrahydrofuran; dioxane / 24 h / 100 °C View Scheme
参考文献
Inoue, Atsushi; Shinokubo, Hiroshi; Oshima, Koichiro
Journal of the American Chemical Society, 2003 , vol. 125, # 6 p. 1484 - 1485
参考文献
Shakespeare, William C.; Sawyer, Tomi K.; Metcalf III, Chester A.; Wang, Yihan; Bohacek, Regine; Sundaramoorthi, Rajeswari
Patent: US2003/114467 A1, 2003 ;
反应条件
α-cyclohexylcyclohexanemethanamine; triphenylphosphine; palladium diacetate in ethanol
T=76°C; 16 h;
参考文献
Goossen, Lukas J.; Dezfuli, Mohammad K.
Synlett, 2005 , # 3 art. no. G45204ST, p. 445 - 448
反应条件
NMM; Pd(PPh3)4 in acetonitrile
参考文献
ARIAD PHARMACEUTICALS,INC.
Patent: US2003/100572 A1, 2003 ;
反应条件
palladium diacetate; caesium carbonate; potassium iodide in acetonitrile
T=20 - 80°C; Inert atmosphere;
参考文献
Berrino, Roberta; Cacchi, Sandro; Fabrizi, Giancarlo; Goggiamani, Antonella; Stabile, Paolo
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 20 p. 4518 - 4520
反应条件
1: 4-amino-benzoic acid ethyl ester With tert.-butylnitrite; boron trifluoride diethyl etherate in tetrahydrofuran
T=-15 - 20°C;
2: triethyl phosphite With palladium diacetate; caesium carbonate; potassium iodide in acetonitrile
T=80°C; 8 h;
参考文献
Berrino, Roberta; Cacchi, Sandro; Fabrizi, Giancarlo; Goggiamani, Antonella; Stabile, Paolo
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 20 p. 4518 - 4520
反应条件
N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; palladium diacetate; triphenylphosphine
T=70 - 80°C; 10 h;
参考文献
Kabachnik; Solntseva; Izmer; Novikova; Beletskaya
Russian Journal of Organic Chemistry, 1998 , vol. 34, # 1 p. 93 - 97
反应条件
phosphorus pentachloride
anschliessend mit Aethanol;
参考文献
Freedman; Jaffe
Journal of the American Chemical Society, 1955 , vol. 77, p. 920
反应条件
bis-triphenylphosphine-palladium(II) chloride; triethylamine in N,N-dimethyl-formamide
0.0666667 h; Irradiation;
参考文献
Villemin, Didier; Jaffres, Paul-Alain; Simeon, Fabrice
Phosphorus, Sulfur and Silicon and Related Elements, 1997 , vol. 130, p. 59 - 63
反应条件
1: With trimethylsilyl bromide in acetonitrile
T=20°C; 3 h;
2: With water in diethyl ether
T=20°C; 0.5 h; Further stages.;
参考文献
Inoue, Atsushi; Shinokubo, Hiroshi; Oshima, Koichiro
Journal of the American Chemical Society, 2003 , vol. 125, # 6 p. 1484 - 1485
