(R)-3-N-叔丁氧羰基氨基丁胺合成路线 （共 4 条）
反应条件
ammonia; hydrogen; Raney-Ni in ethanol; water P=2844.39 Torr;
参考文献
WO2006/116764 A1, ;
Page/Page column 122; 164 ;
反应条件
1: 82 percent / tetrahydrofuran / 1 h / 20 °C 2: 86 percent / Et3N / CH2Cl2 / 2 h / 20 °C 3: 70 percent / dimethylsulfoxide / 15 h / 40 - 45 °C 4: 96 percent / H2; NH3 / Raney Ni / ethanol / 15 h / 20 °C / 4500.36 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 23 p. 4749 - 4763
反应条件
1: 70 percent / dimethylsulfoxide / 15 h / 40 - 45 °C 2: 96 percent / H2; NH3 / Raney Ni / ethanol / 15 h / 20 °C / 4500.36 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 23 p. 4749 - 4763
反应条件
1: 86 percent / Et3N / CH2Cl2 / 2 h / 20 °C 2: 70 percent / dimethylsulfoxide / 15 h / 40 - 45 °C 3: 96 percent / H2; NH3 / Raney Ni / ethanol / 15 h / 20 °C / 4500.36 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 23 p. 4749 - 4763
