2,2,2-三氟-1-(1H-吲哚-5-基)乙酮合成路线 （共 3 条）
反应条件
1: 5-Bromo-1H-indole With potassium hydride in tetrahydrofuran T=0°C; 0.333333 h; 2: With tert.-butyl lithium in tetrahydrofuran; pentane T=-78°C; 0.5 h; 3: trifluoroacetic anhydride With ammonium chloride more than 3 stages;
参考文献
Walter, Rainer; Hamilton, Bradford S.; Trieselmann, Thomas; Netherton, Matthew R.; Santagostino, Marco; Konetzki, Ingo
Patent: US2007/105906 A1, 2007 ;
Location in patent: Page/Page column 14 ;
反应条件
1: 5-Bromo-1H-indole With potassium hydride in tetrahydrofuran; mineral oil T=0°C; 1 h; Inert atmosphere; 2: With tert.-butyl lithium in tetrahydrofuran; mineral oil; pentane T=-78°C; 0.25 h; Inert atmosphere; 3: N-(trifluoroacetyl)piperidine in tetrahydrofuran; mineral oil; pentane T=-78°C; 2 h; Inert atmosphere;
参考文献
Murai, Yuta; Sakihama, Yasuko; Hashidoko, Yasuyuki; Hashimoto, Makoto; Hatanaka, Yasumaru; Masuda, Katsuyoshi
Journal of Organic Chemistry, 2012 , vol. 77, # 19 p. 8581 - 8587,7
Title/Abstract Full Text Show Details
Murai, Yuta; Masuda, Katsuyoshi; Sakihama, Yasuko; Hashidoko, Yasuyuki; Hatanaka, Yasumaru; Hashimoto, Makoto
Journal of Organic Chemistry, 2012 , vol. 77, # 19 p. 8581 - 8587
反应条件
1: 5-Bromo-1H-indole With tert.-butyl lithium; potassium hydride in tetrahydrofuran; pentane T=-78°C; Metallation; 0.416667 h; 2: trifluoroacetic acid T=-78°C; Acylation; 0.5 h;
参考文献
Takami, Hitoshi; Koshimura, Hirokazu; Kumazawa, Toshiaki
Heterocycles, 1999 , vol. 51, # 5 p. 1119 - 1124
