dihydrogen peroxide in trifluoroacetic acid 0.5 h; Ambient temperature;

1: 92 percent / DEPC; Et3N / dimethylformamide / 17 h / -10 - 20 °C 2: 95 percent / imidazole / dimethylformamide / 63 h / 20 °C 3: 97 percent / LiCl; NaBH4 / tetrahydrofuran; ethanol / 23 h / -10 - 20 °C 4: 99 percent / PPh3; (i-PrOCON)2 / tetrahydrofuran / 23 h / 0 - 20 °C 5: 40 percent / 30 percent aq. H2O2 / trifluoroacetic acid / 1 h / 20 °C View Scheme

1.1: pyridine / CH2Cl2 / 12 h / 4 °C 2.1: Mg / tetrahydrofuran 2.2: Li2CuCl4 / tetrahydrofuran 3.1: 100 percent / CH2Cl2 / 0.17 h / 0 °C 4.1: 72 percent / t-BuOK; 18-crown-6 / petroleum ether / 2 h / Heating 5.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C 5.2: tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 0.25 h / -78 °C 6.1: 97 percent / PtO2 / ethyl acetate / 12 h / 20 °C 7.1: 80 percent / HCl; H2O / methanol / 12 h / 60 °C 8.1: 71 percent / DCC / CH2Cl2 / 12 h 9.1: NH3; H2O / CHCl3; methanol / 12 h / 20 °C 10.1: H2O2; H2O / 12 h / 20 °C View Scheme

1.1: Mg / tetrahydrofuran 1.2: Li2CuCl4 / tetrahydrofuran 2.1: 100 percent / CH2Cl2 / 0.17 h / 0 °C 3.1: 72 percent / t-BuOK; 18-crown-6 / petroleum ether / 2 h / Heating 4.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C 4.2: tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 0.25 h / -78 °C 5.1: 97 percent / PtO2 / ethyl acetate / 12 h / 20 °C 6.1: 80 percent / HCl; H2O / methanol / 12 h / 60 °C 7.1: 71 percent / DCC / CH2Cl2 / 12 h 8.1: NH3; H2O / CHCl3; methanol / 12 h / 20 °C 9.1: H2O2; H2O / 12 h / 20 °C View Scheme

1.1: 100 percent / CH2Cl2 / 0.17 h / 0 °C 2.1: 72 percent / t-BuOK; 18-crown-6 / petroleum ether / 2 h / Heating 3.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C 3.2: tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 0.25 h / -78 °C 4.1: 97 percent / PtO2 / ethyl acetate / 12 h / 20 °C 5.1: 80 percent / HCl; H2O / methanol / 12 h / 60 °C 6.1: 71 percent / DCC / CH2Cl2 / 12 h 7.1: NH3; H2O / CHCl3; methanol / 12 h / 20 °C 8.1: H2O2; H2O / 12 h / 20 °C View Scheme

1: 97 percent / PtO2 / ethyl acetate / 12 h / 20 °C 2: 80 percent / HCl; H2O / methanol / 12 h / 60 °C 3: 71 percent / DCC / CH2Cl2 / 12 h 4: NH3; H2O / CHCl3; methanol / 12 h / 20 °C 5: H2O2; H2O / 12 h / 20 °C View Scheme

1: 95 percent / MCPBA / CHCl3 / 4 h / 20 °C 2: 80 percent / HCl; H2O / methanol / 12 h / 60 °C 3: 71 percent / DCC / CH2Cl2 / 12 h 4: NH3; H2O / CHCl3; methanol / 12 h / 20 °C 5: H2O2; H2O / 12 h / 20 °C View Scheme

1: 80 percent / HCl; H2O / methanol / 12 h / 60 °C 2: 71 percent / DCC / CH2Cl2 / 12 h 3: NH3; H2O / CHCl3; methanol / 12 h / 20 °C 4: H2O2; H2O / 12 h / 20 °C View Scheme

1: DEPC, TEA / dimethylformamide / -10 deg C, 1 h; r.t., 16 h 2: 95 percent / imidazole / dimethylformamide / 63 h / Ambient temperature 3: 97 percent / NaBH4, LiCl / tetrahydrofuran; ethanol / -10 deg C, 1 h; r.t., 22 h 4: TEA / CH2Cl2 / 0.5 h / 0 °C 5: CH3COSK / dimethylformamide / 4 h / Ambient temperature 6: 40 percent / 30percent aq. H2O2 / trifluoroacetic acid / 1 h / Ambient temperature View Scheme

1: CH3COSK / dimethylformamide / 4 h / Ambient temperature 2: 40 percent / 30percent aq. H2O2 / trifluoroacetic acid / 1 h / Ambient temperature View Scheme