2,3,4,5-四氢-1H-苯并[b]氮杂卓合成路线 (共 35 条)
反应条件
1: 92.3 percent / hydroxylamine hydrochloride; pyridine / methanol / 2 h / Heating 2: 78.14 percent / polyphosphoric acid / 120 - 130 °C 3: lithium aluminum hydride / tetrahydrofuran / 4 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 36, # 3 p. 355 - 363
反应条件
in diethyl ether 8.5 h; Irradiation;
参考文献
Hill, John; Zakaria, Marwan M.; Mumford, David
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 10 p. 2455 - 2458
反应条件
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 58, # 24 p. 6538 - 6540
反应条件
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 58, # 24 p. 6538 - 6540
反应条件
sodium hydroxide in ethanol; water T=90°C; 24 h;
参考文献
Preedasuriyachai, Patcharee; Chavasiri, Warinthorn; Sakurai, Hidehiro
Synlett, 2011 , # 8 art. no. U00511ST, p. 1121 - 1124
反应条件
1: tetrahydrofuran / 24 h / Ambient temperature 2: MgCl2 / 2-methoxy-ethanol; tetrahydrofuran / 6 h / 125 °C View Scheme
参考文献
Van Wijngaarden; Hamminga; Van Hes; Standaar; Tipker; Tulp; Mol; Olivier; De Jonge
Journal of Medicinal Chemistry, 1993 , vol. 36, # 23 p. 3693 - 3699
反应条件
sulfuric acid; nitric acid
参考文献
Johnson, Paul D.; Aristoff, Paul A.; Zurenko, Gary E.; Schaadt, Ronda D.; Yagi, Betty H.; Ford, Charles W.; Hamel, Judith C.; Stapert, Douglas; Moerman, Judy K.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 23 p. 4197 - 4200
反应条件
dihydrogen peroxide; sodium tungstate in methanol
50 h; Ambient temperature;
参考文献
Murahashi, Shun-Ichi; Oda, Tetsuya; Sugahara, Toshiaki; Masui, Yoshiyuki
Journal of the Chemical Society, Chemical Communications, 1987 , # 19 p. 1471 - 1472
反应条件
in water
19 h; Heating;
参考文献
Hassner, Alfred; Amit, Boaz; Marks, Vered; Gottlieb, Hugo E.
Journal of Organic Chemistry, 2003 , vol. 68, # 18 p. 6853 - 6858
反应条件
1: KNO3 / sulfuric acid
2: sodium hydrogencarbonate / dichloromethane
3: Pd-C / ethanol
View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;