3-氨基-2-疏基-3H-喹唑烷-4-酮合成路线 （共 14 条）
反应条件
hydrazine hydrate T=50°C; 1.5 h;
参考文献
Alagarsamy, Veerachamy; Muthukumar, Veluchamy; Pavalarani, Nagendran; Vasanthanathan, Poongavanam; Revathi, Rajappan
Biological and pharmaceutical bulletin, 2003 , vol. 26, # 4 p. 557 - 559
反应条件
1: K2CO3 / acetone 2: dimethylsulfoxide 3: hydrazine hydrate / ethanol / 5 - 10 °C 4: ethanol / 1.5 h / 50 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 15, # 10 p. 3457 - 3462
反应条件
potassium hydroxide in ethanol 5 h; Heating;
参考文献
Liu; Hu
Archiv der Pharmazie, 1987 , vol. 320, # 2 p. 166 - 171
反应条件
T=200 - 210°C; 0.5 h;
参考文献
Rusu, G. G.; Koval', D.; Gutsu, Ya. E.; Barba, N. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1995 , vol. 31, # 7 p. 873 - 874
Khimiya Geterotsiklicheskikh Soedinenii, 1995 , # 7 p. 1001 - 1002
反应条件
hydrogenchloride 2 h; Heating;
参考文献
Gakhar, H. K.; Gupta, S. C.; Kumar, Naresh
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 1 p. 14 - 16
反应条件
1: hydrazine hydrate 2: ethanol / 1.5 h / 50 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 15, # 10 p. 3457 - 3462
反应条件
1: 82 percent / H2NNH2 / ethanol / 2 h / Heating 2: 73 percent / aq. KOH / ethanol / 5 h / Heating View Scheme
参考文献
Archiv der Pharmazie, , vol. 320, # 2 p. 166 - 171
反应条件
1: aq. NaOH / dimethylsulfoxide / 0.5 h / 20 °C 2: dimethylsulfoxide / 3 h 3: N2H4*H2O / 2 h / 50 °C View Scheme
参考文献
Pharmaceutica Acta Helvetiae, , vol. 74, # 1 p. 11 - 17
反应条件
1: 50 percent / 2percent potassium hydroxide / ethanol / roomtemp., -> 40-45 deg C -> reflux 2: 70 percent / conc. HCl / 2 h / Heating View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 20, # 1 p. 14 - 16
反应条件
sodium hydroxide; dihydrogen peroxide T=20°C; oxidative desulfuration; 0.5 h;
参考文献
Pfeifer, Wolf-Diethard; Hetzheim, Annemarie; Pazdera, Pavel; Bodtke, Anja; Muecke, Jana
Journal of Heterocyclic Chemistry, 1999 , vol. 36, # 5 p. 1327 - 1336
