Boc-dl-3-氨基异丁酸合成路线 （共 6 条）
反应条件
sodium hydroxide; tert-butyl alcohol in water T=30°C; 18 h;
参考文献
Journal of Organic Chemistry, , vol. 66, # 20 p. 6541 - 6544
反应条件
hydrogen; 5 rhodium on alumina in tetrahydrofuran P=2844.39 Torr; 18 h; Heating / reflux;
参考文献
US6372936 B1, ;
Page column 4 ;
反应条件
NaHSO4 in 1,4-dioxane; water; ethyl acetate
反应条件
triethylamine in tert-butyl alcohol
参考文献
Journal of the Chemical Society [Section] C: Organic, , p. 2632 - 2636
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/108677 A1, 2004 ;
Location in patent: Page 132-133 ;
WO 2004/108677 A1
反应条件
1.1: Cs2CO3 / methanol; H2O 1.2: 84 percent / dimethylformamide / 22 h 2.1: 81 percent / DMAP / acetonitrile / 24 h / 20 °C 3.1: 86 percent / H2 / 10percent palladium hydroxide on carbon / methanol / 2 h / 20 °C 4.1: 62 percent / DMF; oxalyl chloride; pyridine / acetonitrile / 7 h / -20 - 20 °C View Scheme
参考文献
McKiernan; Huck; Fehrentz; Roumestant; Viallefont; Martinez
Journal of Organic Chemistry, 2001 , vol. 66, # 20 p. 6541 - 6544
