(S)-boc-3-氨基-2-(对甲苯磺酰基氨基)-丙酸合成路线 （共 8 条）
反应条件
sodium hydroxide in 1,4-dioxane T=45°C; 48 h;
参考文献
Rich; Jasensky; Mueller; Anderson
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 567 - 572
反应条件
sodium hydroxide in 1,4-dioxane 3 h; Ambient temperature;
参考文献
Kato; Harada; Morie
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 5 p. 1469 - 1478
反应条件
1: 78 percent / Br2, aq. NaOH / 0.25 h / 80 °C 2: 96 percent / aq. NaOH / dioxane / 3 h / Ambient temperature View Scheme
参考文献
Rich; Jasensky; Mueller; Anderson
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 567 - 572
反应条件
1: 91 percent / 2N aq. NaOH / dioxane / a) 0 deg C, 1 h, b) RT, 3 h 2: 78 percent / Br2, aq. NaOH / 0.25 h / 80 °C 3: 96 percent / aq. NaOH / dioxane / 3 h / Ambient temperature View Scheme
参考文献
Kato; Harada; Morie
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 5 p. 1469 - 1478
反应条件
1: Na, NH3(liq.) / 0.17 h / -50 °C 2: 61 percent / 4 N aq. NaOH / 2 h / 25 °C / pH 10-10.5 3: 79.5 percent / diethyl ether View Scheme
参考文献
Moore,S. et al.
Journal of Medicinal Chemistry, 1976 , vol. 19, p. 766 - 772
反应条件
1: Na, NH3(liq.) / 0.17 h / -50 °C 2: 61 percent / 4 N aq. NaOH / 2 h / 25 °C / pH 10-10.5 3: 79.5 percent / diethyl ether 4: 100 percent / H2 / 10percent Pd/C / methanol / 24 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 24, # 5 p. 567 - 572
反应条件
1: Na, NH3(liq.) / 0.17 h / -50 °C 2: 61 percent / 4 N aq. NaOH / 2 h / 25 °C / pH 10-10.5 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 24, # 5 p. 567 - 572
反应条件
(i) Na, liq. NH3, (ii) /BRN= 509751/; Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 19, p. 766 - 772
