2-(N-Cbz)-3-(N-Boc)-2,3-二氨基丙酸合成路线 （共 19 条）
反应条件
sodium carbonate in 1,4-dioxane; water T=20°C; 1 h;
参考文献
Organic Letters, , vol. 8, # 22 p. 5009 - 5012
反应条件
1: With lithium hydroxide; water in tetrahydrofuran T=20°C; 1.5 h; 2: With citric acid in water; ethyl acetate
参考文献
EP1577302 A1, ;
Page/Page column 222-223 ;
反应条件
sodium hydroxide in water; acetone T=0°C; 3 h;
参考文献
Synthesis, , # 11 p. 1351 - 1352
反应条件
sodium hydroxide T=25°C; 2 h; pH 10-10.5;
参考文献
Journal of Medicinal Chemistry, , vol. 24, # 5 p. 567 - 572
反应条件
1: 88.4 percent / 1 N aq. NaoH / dioxane / 48 h / 45 °C 2: Na, NH3(liq.) / 0.17 h / -50 °C 3: 61 percent / 4 N aq. NaOH / 2 h / 25 °C / pH 10-10.5 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 24, # 5 p. 567 - 572
反应条件
1: 47 percent / [bis(trifluoroacetoxy)iodo]-benzene; pyridine / dimethylformamide; H2O / 4.5 h / 20 °C 2: 91 percent / Na2CO3 / H2O; dioxane / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 56, # 16 p. 2513 - 2522
反应条件
1: 84 percent / Na2CO3 / H2O; dioxane / 20 °C 2: 47 percent / [bis(trifluoroacetoxy)iodo]-benzene; pyridine / dimethylformamide; H2O / 4.5 h / 20 °C 3: 91 percent / Na2CO3 / H2O; dioxane / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 56, # 16 p. 2513 - 2522
反应条件
1: 1.) diphenylphosphoryl azide, Et3N; 2.) SnCl4 / 1.) 80 deg C, 2 h, toluene; 2.) 70 deg C, 0.5 h 2: 88 percent / 1N NaOH / H2O; acetone / 3 h / 0 °C View Scheme
参考文献
Synthesis, , # 11 p. 1351 - 1352
反应条件
triethylamine in 1,4-dioxane; water Yield given;
参考文献
Synthesis, , vol. No.4, p. 266 - 268
反应条件
1: Na, NH3(liq.) / 0.17 h / -50 °C 2: 61 percent / 4 N aq. NaOH / 2 h / 25 °C / pH 10-10.5 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 24, # 5 p. 567 - 572
