(S)-3-异丙基-2,5-哌嗪二酮合成路线 （共 29 条）
反应条件
in water T=150°C; 0.25 h; microwave irradiation;
参考文献
Tetrahedron Letters, , vol. 47, # 29 p. 5199 - 5201
反应条件
1: 1.) ethyl chloroformate, Et3N, 2.) Et3N / 1.) CHCl3, 30 min, room temp., 2.) CHCl3, THF, room temp., 30 min, then reflux, 10 min 2: 100 percent / 0.5 h / 200 °C View Scheme
参考文献
Tetrahedron, , vol. 54, # 40 p. 12349 - 12360
反应条件
1: Et3N / CHCl3; tetrahydrofuran / 13 h / -78 - -20 °C 2: toluene / 24 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 9, # 2 p. 321 - 327
反应条件
1.1: triethylamine / dichloromethane / 0.5 h 1.2: 18 h / 20 °C 2.1: 1,2-dichloro-benzene / 18 h / 175 - 180 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 9, # 2 p. 185 - 187
反应条件
1: triethylamine / CHCl3; tetrahydrofuran / -70 deg C, 3 h; room temp., 30 min 2: toluene / 12 h / Heating View Scheme
参考文献
Angewandte Chemie, , vol. 93, # 9 p. 793 - 795
反应条件
1: 1.) 4-methylmorpholine, ethylchloroformate, 2.) 4-methylmorpholine / 1.) EtOAc, -15 deg C, 15 min, 2.) a.) -15 deg C, 1 h, b.) RT, 12 h 2: 1.) 10percent Pd/C / 1.) cyclohexene, MeOH, reflux, 5 h, 2.) MeOH, from 62 to 65 deg C, 110 h View Scheme
参考文献
Gazzetta Chimica Italiana, , vol. 120, p. 765 - 769
参考文献
Tetrahedron, , vol. 39, # 12 p. 2085 - 2092
反应条件
in toluene 12 h; Heating; Yield given;
参考文献
Angewandte Chemie, , vol. 93, # 9 p. 793 - 795
反应条件
tetra-(n-butyl)ammonium iodide; sodium hydride in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
Ishida, Yasuhiro; Aida, Takuzo
Journal of the American Chemical Society, 2002 , vol. 124, # 47 p. 14017 - 14019
反应条件
1: 80 percent / NaH / dimethylformamide / 4 h / 0 °C 2: 77 percent / LHMDS / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) -78 deg C, 3 h 3: 94 percent / ceric ammonium nitrate / acetonitrile; H2O / 4 h 4: HCl, H2O / 24 h / Heating View Scheme
参考文献
Bull, Steven D.; Davies, Stephen G.; Epstein, Simon W.; Ouzman, Jacqueline V. A.
Chemical Communications, 1998 , # 6 p. 659 - 660
