(S)-3-异丙基-2,5-哌嗪二酮合成路线 （共 29 条）
反应条件
silica gel in gas T=200 - 210°C; P=0.08 Torr;
参考文献
Basiuk, Vladimir; Gromovoy, Taras Yu.
Collection of Czechoslovak Chemical Communications, 1994 , vol. 59, # 2 p. 461 - 466
反应条件
in water T=250°C; P=7757.43 Torr; 0.166667 h; Microwave irradiation;
参考文献
Perez-Picaso, Lemuel; Escalante, Jaime; Olivo, Horacio F.; Rios, Maria Yolanda
Molecules, 2009 , vol. 14, # 8 p. 2836 - 2849
反应条件
1: With triethylamine in tetrahydrofuran; chloroform T=-70°C; 2: in toluene Heating; Further stages.;
参考文献
Ma; Liu; Li; Flippen-Anderson; Yu; Cook
Journal of Organic Chemistry, 2001 , vol. 66, # 13 p. 4525 - 4542
反应条件
triethylamine in tetrahydrofuran; chloroform 1.) -70 deg C, 3 h, 2.) RT, 2 h;
参考文献
Allen; Hamaker; La Loggia; Cook
Synthetic Communications, 1992 , vol. 22, # 14 p. 2077 - 2102
参考文献
Cledera, Pilar; Avendano, Carmen; Menendez, J. Carlos
Tetrahedron, 1998 , vol. 54, # 40 p. 12349 - 12360
反应条件
1: N,N-dicyclohexylcarbodiimide / CH2Cl2 2: HCl / CH2Cl2 / 0 °C 3: 1.) aq. sodium bicarbonate / 1.) room temperature; 2.) reflux, methanol, 24 h View Scheme
参考文献
Journal of the American Chemical Society, , vol. 108, # 23 p. 7327 - 7332
反应条件
1: HCl / CH2Cl2 / 0 °C 2: 1.) aq. sodium bicarbonate / 1.) room temperature; 2.) reflux, methanol, 24 h View Scheme
参考文献
Journal of the American Chemical Society, , vol. 108, # 23 p. 7327 - 7332
反应条件
1: 96 percent / tetrahydrofuran; toluene / 4 h / 50 - 60 °C 2: Et3N / CHCl3; tetrahydrofuran / 13 h / -78 - -20 °C 3: toluene / 24 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 9, # 2 p. 321 - 327
反应条件
hydrogen bromide; acetic acid in methanol 12 h; Ambient temperature;
参考文献
Ishibashi, Norio; Kouge, Katsushige; Shinoda,Ichizo; Kanehisa, Hidenori; Okai, Hideo
Agricultural and Biological Chemistry, 1988 , vol. 52, # 3 p. 819 - 828
反应条件
sodium hydrogencarbonate 1.) room temperature; 2.) reflux, methanol, 24 h; Multistep reaction;
参考文献
Journal of the American Chemical Society, , vol. 108, # 23 p. 7327 - 7332
