(4-噻吩-2-苯基)甲醇合成路线 （共 55 条）
反应条件
aluminium trichloride in dichloromethane 0 deg C, 30 min; r.t., 60 min; reflux, 30 min;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 59, p. 83 - 88
反应条件
palladium; triphenylphosphine in toluene T=110°C; Negishi Coupling; 24 h; Inert atmosphereGreen chemistry; Catalytic behavior;
参考文献
ChemCatChem, , vol. 5, # 4 p. 1011 - 1019
反应条件
1: With sulfuric acid in methanol 1 h; Heating; 2: With chloranil in benzene 2 h; Heating;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 11, # 22 p. 4729 - 4742
反应条件
1.1: AlCl3 / CS2 / 2.5 h / 20 °C 2.1: dimethylformamide / 22 h / 5 °C 3.1: H2SO4 / methanol / 1 h / Heating 3.2: chloranil / benzene / 2 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 11, # 22 p. 4729 - 4742
反应条件
1.1: dimethylformamide / 22 h / 5 °C 2.1: H2SO4 / methanol / 1 h / Heating 2.2: chloranil / benzene / 2 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 11, # 22 p. 4729 - 4742
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / |Schlenk technique; |Inert atmosphere 1.2: -90 - 20 °C / |Schlenk technique; |Inert atmosphere 2.1: potassium hydroxide; palladium diacetate; dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine / neat (no solvent) / 24 h / 110 °C / |Schlenk technique; |Inert atmosphere View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 355, # 18 p. 3553 - 3557
反应条件
1: sodium sulfate / tetrahydrofuran / 24 h / 20 °C / |Schlenk technique; |Inert atmosphere 2: potassium hydroxide; palladium diacetate; dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine / neat (no solvent) / 24 h / 110 °C / |Schlenk technique; |Inert atmosphere View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 355, # 18 p. 3553 - 3557
反应条件
1: 1.) 1 M aq. HCl, NaNO2 / 1.) 0 deg C, 30 min, 2.) 0 deg C, 30 min 2: 26 percent / CF3COOH / 3 h / 65 - 70 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 50, # 13 p. 2232 - 2235
反应条件
bis(acetylacetonate)nickel(II); water; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride; zinc(II) chloride 1.) THF, 0 deg C then rt, 15 min, 2.) THF, 25 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 39, # 36 p. 6441 - 6444
反应条件
1: 1.) hexamethylphosphotriamide; 2.) ammonium chloride / 1.) THF, -50 deg C, 4 h; 2.) water, -80 deg C 2: 1.) methyl iodide; 2.) triethylamine / 1.) overnight; 2.) toluene, 1 h, reflux, 12 h View Scheme
参考文献
Phosphorus and Sulfur and the Related Elements, , vol. 26, p. 299 - 306
