2-(3-氟-4-硝基苯基)乙酸甲酯合成路线 （共 5 条）
反应条件
sulfuric acid; nitric acid in water T=0°C; 2 h;
参考文献
DIGITALBIOTECH CO., LTD.
Patent: WO2005/3084 A1, 2005 ;
Location in patent: Page 24; 71-72 ;
WO 2005/003084 A1
反应条件
sulfuric acid; nitric acid T=0°C; 2 h;
参考文献
Zhu, Jieping; Beugelmans, Rene; Bourdet, Sebastien; Chastanet, Jacqueline; Roussi, George
Journal of Organic Chemistry, 1995 , vol. 60, # 20 p. 6389 - 6396
反应条件
sodium tetrahydroborate; nickel dichloride in methanol T=0°C; 1 h;
参考文献
Asahi Kasei Pharma Corporation
Patent: WO2006/123639 A1, 2006 ;
Location in patent: Page/Page column 172-173 ;
WO 2006/123639 A1
反应条件
hydrogenchloride Heating;
参考文献
Zhu, Jieping; Beugelmans, Rene; Bourdet, Sebastien; Chastanet, Jacqueline; Roussi, George
Journal of Organic Chemistry, 1995 , vol. 60, # 20 p. 6389 - 6396
反应条件
1: 2-(3-fluoro-4-nitrophenyl)acetic acid methyl ester With sodium hydride in tetrahydrofuran
0.166667 h;
2: ethylene dibromide in tetrahydrofuran
T=20°C; 0.5 h;
参考文献
DIGITALBIOTECH CO., LTD.
Patent: WO2005/3084 A1, 2005 ;
Location in patent: Page 24; 72 ;
WO 2005/003084 A1
