2,6-二甲氧基-1-碘苯合成路线 （共 33 条）
反应条件
1: Pd0(tris(tert-butyl)phosphine)2; α-cyclohexylcyclohexanemethanamine; lithium chloride / 1,4-dioxane / 16 h / 110 °C / |Inert atmosphere 2: hydrogenchloride / 1,2-dichloro-ethane / 0.25 h / 20 °C View Scheme
参考文献
Kohrt, Jeffrey T.; Conn, Ed; Maguire, Robert; Wright, Stephen W.; Singer, Robert
Tetrahedron Letters, 2013 , vol. 54, # 51 p. 7065 - 7068
参考文献
Banzatti; Carfagna; Commisso; Heidempergher; Pegrassi; Melloni
Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1466 - 1471
反应条件
tetra-(n-butyl)ammonium iodide; sodium hydride; zinc; NiCl2((PPh3)P)2; triphenylphosphine in toluene
T=90°C; Ullmann-type coupling reaction; 1 h;
参考文献
Hong; Hoen; Zhang; Lin
Synlett, 2001 , # 10 p. 1527 - 1530
反应条件
1: 1,3-dimethoxy benzene With n-butyllithium in tetrahydrofuran; hexane
T=0°C; 1 h;
2: 2-iodo-1,3-dimethoxybenzene With copper(l) iodide in tetrahydrofuran; pyridine; hexane
72 h; Heating; Further stages.;
参考文献
Govender, Sameshnee; Mmutlane, Edwin M.; Van Otterlo, Willem A. L.; De Koning, Charles B.
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 15 p. 2433 - 2440
反应条件
copper
T=250°C; Erwaermen einer aethanol. Loesung des Reaktionsprodukts mit wss. Natronlauge;
参考文献
van Arendonk; Becker; Adams
Journal of the American Chemical Society, 1933 , vol. 55, p. 4230,4231, 4232
反应条件
pyridine
T=50°C; 72 h; Yield given;
参考文献
Frantsi, Marianne; Lindsten, Goeran; Wennerstroem, Olof
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1982 , vol. 36, # 2 p. 135 - 136
反应条件
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; potassium fluoride; [(t-Bu)3PH]BF4 in tetrahydrofuran
Reflux;
参考文献
Matsuda, Takanori; Moriya, Taisaku; Goya, Tsuyoshi; Murakami, Masahiro
Chemistry Letters, 2011 , vol. 40, # 1 p. 40 - 41
反应条件
1: bromobenzene With magnesium in diethyl ether
1 h; Heating;
2: 2-iodo-1,3-dimethoxybenzene With NiCl2((PPh3)P)2 in diethyl ether
Kharasch reaction; 24 h; Heating;
参考文献
Greig, Lyndsey M.; Slawin, Alexandra M.Z.; Smith, Melanja H.; Philp, Douglas
Tetrahedron, 2007 , vol. 63, # 11 p. 2391 - 2403
反应条件
NiCl2((PPh3)P)2 in diethyl ether
22 h; Heating;
参考文献
Novak, Jiri; Salemink, Cornelis A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2873 - 2878
反应条件
N,N,N',N,-tetramethylethylenediamine
T=20°C; 30 h; UV-irradiation;
参考文献
Zheng, Xingliang; Yang, Luo; Du, Weiyuan; Ding, Aishun; Guo, Hao
Chemistry - An Asian Journal, 2014 , vol. 9, # 2 p. 439 - 442
