5-硝基-N-苯基邻氨基苯甲酸合成路线 （共 14 条）
反应条件
copper diacetate; potassium carbonate T=185°C; Ullmann Condensation; 2 h; Inert atmosphere;
参考文献
Almac Sciences (Scotland) Limited; RAMAGE, Robert; MALTMAN, Beatrice; COTTON, Graham; COUTURIER, Sarah, Claire, Monique; MCMORDIE, Robert, Austin, Simms
Patent: EP1940965 B1, 2014 ;
Location in patent: Paragraph 0085-0087 ;
反应条件
water; lithium hydroxide hydrate in tetrahydrofuran; methanol Reflux;
参考文献
Oh, Soo-Jin; Hwang, Seok Jin; Jung, Jonghoon; Yu, Kuai; Kim, Jeongyeon; Choi, Jung Yoon; Hartzell, H. Criss; Roh, Eun Joo; Justin Lee
Molecular Pharmacology, 2013 , vol. 84, # 5 p. 726 - 735
反应条件
copper(l) iodide; potassium carbonate; L-proline in water; N,N-dimethyl-formamide T=160°C; 1 h; Microwave irradiation;
参考文献
Marques, Emerson F.; Bueno, Mauro A.; Duarte, Patricia D.; Silva, Larissa R.S.P.; Martinelli, Ariani M.; Dos Santos, Caio Y.; Severino, Richele P.; Broemme, Dieter; Vieira, Paulo C.; Correa, Arlene G.
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 10 - 21
反应条件
1: chloride derivative / 0 °C / |Reflux 2: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; caesium carbonate / 20 - 130 °C 3: lithium hydroxide hydrate; water / methanol; tetrahydrofuran / |Reflux View Scheme
参考文献
Oh, Soo-Jin; Hwang, Seok Jin; Jung, Jonghoon; Yu, Kuai; Kim, Jeongyeon; Choi, Jung Yoon; Hartzell, H. Criss; Roh, Eun Joo; Justin Lee
Molecular Pharmacology, 2013 , vol. 84, # 5 p. 726 - 735
反应条件
1: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; caesium carbonate / 20 - 130 °C 2: lithium hydroxide hydrate; water / methanol; tetrahydrofuran / |Reflux View Scheme
参考文献
Oh, Soo-Jin; Hwang, Seok Jin; Jung, Jonghoon; Yu, Kuai; Kim, Jeongyeon; Choi, Jung Yoon; Hartzell, H. Criss; Roh, Eun Joo; Justin Lee
Molecular Pharmacology, 2013 , vol. 84, # 5 p. 726 - 735
反应条件
N-hexadecyl-N,N,N-trimethylammonium bromide in water T=73°C; or without CTAB-catalysis; Rate constantMechanism;
参考文献
Broxton, Trevor J.; Marcou, Victor
Journal of Organic Chemistry, 1991 , vol. 56, # 3 p. 1041 - 1044
反应条件
1: sulfuric acid; nitric acid 2: potassium carbonate; copper / 180 °C View Scheme
参考文献
Dey; Doraiswami
Journal of the Indian Chemical Society, 1933 , vol. 10, p. 309,320
参考文献
Schoepff
Chemische Berichte, 1890 , vol. 23, p. 3442
反应条件
trichlorophosphate T=140°C; 5 h; Inert atmosphere;
参考文献
Almac Sciences (Scotland) Limited; RAMAGE, Robert; MALTMAN, Beatrice; COTTON, Graham; COUTURIER, Sarah, Claire, Monique; MCMORDIE, Robert, Austin, Simms
Patent: EP1940965 B1, 2014 ;
Location in patent: Paragraph 0088-0089 ;
反应条件
1: trichlorophosphate / 5 h / 140 °C / |Inert atmosphere 2: phenol; (NH4)2CO3 / 1 h / 70 - 120 °C / |Inert atmosphere 3: sodium hydroxide / water / 2 h / 20 °C 4: palladium/alumina; ammonium formate / ethyl acetate; methanol / 1.33 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Almac Sciences (Scotland) Limited; RAMAGE, Robert; MALTMAN, Beatrice; COTTON, Graham; COUTURIER, Sarah, Claire, Monique; MCMORDIE, Robert, Austin, Simms
Patent: EP1940965 B1, 2014 ;
