4-(2-硝基苯基)苯甲醛合成路线 (共 7 条)
反应条件
sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in DMF (N,N-dimethyl-formamide); water T=80°C; 18 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/40110 A1, 2005 ;
Location in patent: Page/Page column 65 ;
反应条件
1: ortho-nitrobenzoic acid With cupric(II) carbonate in various solvent(s) T=120°C; 0.5 h; 2: 4-bromo-benzaldehyde With potassium fluoride; palladium acetylacetonate; iso-propyldiphenylphoshine in various solvent(s) T=120°C; 24 h; Further stages.;
参考文献
Goossen, Lukas J.; Rodriguez, Nuria; Melzer, Bettina; Linder, Christophe; Deng, Guojun; Levy, Laura M.
Journal of the American Chemical Society, 2007 , vol. 129, # 15 p. 4824 - 4833
反应条件
quinoline; copper(l) iodide; PdI2; biphenyl-2-yl-di-tert-butyl-phosphane in 1-methyl-pyrrolidin-2-one T=160°C; 24 h; Inert atmosphere;
参考文献
Goossen, Lukas J.; Zimmermann, Bettina; Knauber, Thomas
Angewandte Chemie - International Edition, 2008 , vol. 47, # 37 p. 7103 - 7106
反应条件
potassium acetate in methanol; acetic acid
参考文献
Merck and Co., Inc.
Patent: US5672596 A1, 1997 ;
反应条件
nitric acid T=-5 - 0°C;
参考文献
Grieve; Hey
Journal of the Chemical Society, 1933 , p. 968,971
反应条件
tetrachloromethane; chromium oxychloride
参考文献
Grieve; Hey
Journal of the Chemical Society, 1935 , p. 114
参考文献
Grieve; Hey
Journal of the Chemical Society, 1935 , p. 114