(3R,4R,5R)-5-(羟基甲基)哌啶-3,4-二醇盐酸盐合成路线 （共 76 条）
反应条件
1.1: hydrogenchloride; methanol / water / 6 h / 20 °C 2.1: sodium periodate / water; methanol / 1 h / 0 °C 3.1: sodium tetrahydroborate / water; methanol / 0.5 h / 20 °C 3.2: 3 h / |Reflux 4.1: ammonia / water; methanol / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 23, # 17 p. 1234 - 1237
反应条件
1.1: sodium periodate / water; methanol / 1 h / 0 °C 2.1: sodium tetrahydroborate / water; methanol / 0.5 h / 20 °C 2.2: 3 h / |Reflux 3.1: ammonia / water; methanol / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 23, # 17 p. 1234 - 1237
反应条件
1.1: orthoformic acid triethyl ester; toluene-4-sulfonic acid / dichloromethane / 1.5 h / 20 °C / |Inert atmosphere 2.1: hydrogen; 10 Pd/C / methanol / 24 h / 20 °C / 2068.65 Torr 3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 18 h / 0 - 20 °C / |Inert atmosphere 4.1: hydrogenchloride; methanol / water / 6 h / 20 °C 5.1: sodium periodate / water; methanol / 1 h / 0 °C 6.1: sodium tetrahydroborate / water; methanol / 0.5 h / 20 °C 6.2: 3 h / |Reflux 7.1: ammonia / water; methanol / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 23, # 17 p. 1234 - 1237
反应条件
1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 18 h / 0 - 20 °C / |Inert atmosphere 2.1: hydrogenchloride; methanol / water / 6 h / 20 °C 3.1: sodium periodate / water; methanol / 1 h / 0 °C 4.1: sodium tetrahydroborate / water; methanol / 0.5 h / 20 °C 4.2: 3 h / |Reflux 5.1: ammonia / water; methanol / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 23, # 17 p. 1234 - 1237
反应条件
potassium hydroxide 3 h; Heating; Title compound not separated from byproducts;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 3 p. 733 - 744
反应条件
sodium cyanoborohydride; acetic acid in methanol; chloroform T=20°C; 24 h;
参考文献
Liu, Huizhen; Lillelund, Vinni H.; Andersch, Jens; Liang, Xifu; Bols, Mikael
Journal of Carbohydrate Chemistry, 2004 , vol. 23, # 4 p. 223 - 238
