(3R,4R,5R)-5-(羟基甲基)哌啶-3,4-二醇盐酸盐合成路线 （共 76 条）
反应条件
1: 96 percent / nBu4NF / tetrahydrofuran / 20 °C 2: 72 percent / m-chloroperbenzoic acid / CH2Cl2 / Heating 3: KOH (1 percent) / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 2 p. 357 - 360
反应条件
1: 92 percent / NaH / dimethylformamide / 20 °C 2: 95 percent / Grubb's catalyst / CH2Cl2 / Heating 3: 96 percent / nBu4NF / tetrahydrofuran / 20 °C 4: 72 percent / m-chloroperbenzoic acid / CH2Cl2 / Heating 5: KOH (1 percent) / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 2 p. 357 - 360
反应条件
1: 95 percent / Grubb's catalyst / CH2Cl2 / Heating 2: 96 percent / nBu4NF / tetrahydrofuran / 20 °C 3: 72 percent / m-chloroperbenzoic acid / CH2Cl2 / Heating 4: KOH (1 percent) / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 2 p. 357 - 360
反应条件
1: Et3N / CH2Cl2 / -30 °C 2: 89 percent / NaN3 / dimethylformamide / 50 °C 3: Pseudomonas capacia / Microbiological reaction 4: PPh3; H2O / tetrahydrofuran / 55 °C 5: Et3N / 20 °C 6: 88 percent / imidazole / 20 °C 7: 92 percent / NaH / dimethylformamide / 20 °C 8: 95 percent / Grubb's catalyst / CH2Cl2 / Heating 9: 96 percent / nBu4NF / tetrahydrofuran / 20 °C 10: 72 percent / m-chloroperbenzoic acid / CH2Cl2 / Heating 11: KOH (1 percent) / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 2 p. 357 - 360
反应条件
1: 72 percent / m-chloroperbenzoic acid / CH2Cl2 / Heating 2: KOH (1 percent) / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 2 p. 357 - 360
反应条件
1: 94 percent / Et3N / methanol / 0.5 h / 60 °C 2: 97 percent / LDA / tetrahydrofuran / 0.08 h / -78 °C 3: 70 percent / lithium borohydride; LiEt3BH / diethyl ether; tetrahydrofuran / 1 h / Heating 4: 70 percent / 3-chloroperoxybenzoic acid / CH2Cl2 / 20 °C 5: aq. KOH / 3 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 3 p. 733 - 744
反应条件
1.1: α-chloroethyl chloroformiate / toluene / 3 h / Heating 1.2: 95 percent / methanol / 20 °C 2.1: 94 percent / Et3N / methanol / 0.5 h / 60 °C 3.1: 97 percent / LDA / tetrahydrofuran / 0.08 h / -78 °C 4.1: 70 percent / lithium borohydride; LiEt3BH / diethyl ether; tetrahydrofuran / 1 h / Heating 5.1: 70 percent / 3-chloroperoxybenzoic acid / CH2Cl2 / 20 °C 6.1: aq. KOH / 3 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 3 p. 733 - 744
反应条件
1: 97 percent / LDA / tetrahydrofuran / 0.08 h / -78 °C 2: 70 percent / lithium borohydride; LiEt3BH / diethyl ether; tetrahydrofuran / 1 h / Heating 3: 70 percent / 3-chloroperoxybenzoic acid / CH2Cl2 / 20 °C 4: aq. KOH / 3 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 3 p. 733 - 744
反应条件
1: 70 percent / 3-chloroperoxybenzoic acid / CH2Cl2 / 20 °C 2: aq. KOH / 3 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 3 p. 733 - 744
反应条件
1: 70 percent / lithium borohydride; LiEt3BH / diethyl ether; tetrahydrofuran / 1 h / Heating 2: 70 percent / 3-chloroperoxybenzoic acid / CH2Cl2 / 20 °C 3: aq. KOH / 3 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 3 p. 733 - 744
