(3R,4R,5R)-5-(羟基甲基)哌啶-3,4-二醇盐酸盐合成路线 （共 76 条）
反应条件
hydrogen; palladium hydroxide - carbon in ethanol Hydrogenolysis; P=3878.61 Torr; 10 h;
参考文献
Pandey; Kapur
Synthesis, 2001 , # 8 p. 1263 - 1267
反应条件
hydrogenchloride; hydrogen; palladium dihydroxide in methanol T=20°C; 22 h;
参考文献
Zhu, Xiaoxiang; Sheth, Kamlesh A.; Li, Shihong; Chang, Hui-Hwa; Fan, Jian-Qiang
Angewandte Chemie - International Edition, 2005 , vol. 44, # 45 p. 7450 - 7453
反应条件
hydrogenchloride in 1,4-dioxane 1 h; Heating;
参考文献
Ouchi, Hidekazu; Mihara, Yukiko; Takahata, Hiroki
Journal of Organic Chemistry, 2005 , vol. 70, # 13 p. 5207 - 5214
反应条件
1: 3.3 g / 4 Angstroem molecular sieves; 18-crown-6 / dimethylformamide / 16 h / 20 °C 2: 81 percent / H2; aq. HCl / Pd(OH)2/C / methanol / 22 h / 20 °C View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 44, # 45 p. 7450 - 7453
参考文献
Zhao; Deo; Ganem
Organic letters, 2001 , vol. 3, # 2 p. 201 - 203
反应条件
boron tribromide in dichloromethane T=0°C; 16 h; RefluxInert atmosphere;
参考文献
Organic Letters, , vol. 14, # 2 p. 596 - 599
反应条件
1: With hydrogen; palladium on activated charcoal in methanol; acetic acid P=760 Torr; 2: With hydrogenchloride
参考文献
Canadian Journal of Chemistry, , vol. 80, # 8 p. 857 - 865
反应条件
1: 43 percent / Et3N / 1 h / 0 °C 2: 82 percent / p-TsOH*H2O / 0 - 20 °C 3: 88 percent / Ac2O; silica gel 60 4: 53 percent / H2 / 10percent Pd/C / methanol / 16 h / 20 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 7, # 17 p. 3744 - 3747
反应条件
1.1: (Bu3Sn)2O; molecular sieves 3 Angstroem / CHCl3 / 3.5 h / Heating 1.2: 91 percent / Br2 / CHCl3 / 0.05 h / 0 °C 2.1: 43 percent / Et3N / 1 h / 0 °C 3.1: 82 percent / p-TsOH*H2O / 0 - 20 °C 4.1: 88 percent / Ac2O; silica gel 60 5.1: 53 percent / H2 / 10percent Pd/C / methanol / 16 h / 20 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 7, # 17 p. 3744 - 3747
反应条件
1: 82 percent / p-TsOH*H2O / 0 - 20 °C 2: 88 percent / Ac2O; silica gel 60 3: 53 percent / H2 / 10percent Pd/C / methanol / 16 h / 20 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 7, # 17 p. 3744 - 3747
