反-2,4-二甲氧基肉桂酸合成路线 （共 16 条）
反应条件
1: 1.) triethylamine, ethyl chloroformate / 1.) tert-BuOH-MeCN, 0 deg C, 0.5 h; 2.) tert-BuOH-MeCN, room temp., 1 h 2: 51 percent / sodium bis(2-methoxyethoxy)aluminium hydride / toluene / 0.5 h View Scheme
参考文献
Ohtaka; Kanazawa; Ito; Tsukamoto
Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 10 p. 4124 - 4129
反应条件
sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride 1) dioxane, H2O, 2) dioxane, H2O, reflux; Multistep reaction;
参考文献
Kyowa Hakko Kogyo Co., Ltd.
Patent: US5484920 A1, 1996 ;
US 5484920 A
反应条件
sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride 1) dioxane, H2O, 2) dioxane, H2O, reflux; Multistep reaction;
参考文献
Shimada, Junichi; Koike, Nobuaki; Nonaka, Hiromi; Shiozaki, Shizuo; Yanagawa, Koji; Kanda, Tomoyuki; Kobayashi, Hiroyuki; Ichimura, Michio; Nakamura, Joji; Kase, Hiroshi; Suzuki, Fumio
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 18 p. 2349 - 2352
参考文献
Elsworth; Lamchen
Journal of the South African Chemical Institute, 1972 , vol. 25, p. 31,42
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Journal of Organic Chemistry, , vol. 52, # 6 p. 1072 - 1078
反应条件
1: With pyridine; 3-aminopropionic acid
1.5 h; RefluxInert atmosphere;
2: With hydrogenchloride in water
T=0°C; Inert atmosphere;
参考文献
De Simone, Filippo; Andres, Julien; Torosantucci, Riccardo; Waser, Jerome
Organic Letters, 2009 , vol. 11, # 4 p. 1023 - 1026
反应条件
pyridine; hydrogenchloride; malonic acid in methanol; cyclohexane; water
参考文献
Hoechst Aktiengesellschaft
Patent: US5124478 A1, 1992 ;
反应条件
piperazine in ethylene glycol
Knoevenagel condensation; 0.0666667 h; microwave irradiation;
参考文献
Khosropour, Ahmad Reza; Khodaei, Mohammad Mehdi; Moghanian, Hassan
Journal of Chemical Research, 2005 , # 6 p. 364 - 365
反应条件
1: sodium / Erhitzen des Reaktionsprodukts in dem vielleicht das Stereoisomere vorgelegen hat, unter 22 Torr auf 220grad
View Scheme
参考文献
Reimer; Tobin
Journal of the American Chemical Society, 1930 , vol. 52, p. 341,345
反应条件
sodium hydride in tetrahydrofuran
1.) 15 min, 2.) 10 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Sehgal, C. K.; Kachroo, P. L.; Taneja, S.C.; Dhar, K. L.; Atal, C. K.
Synthetic Communications, 1980 , vol. 10, # 1 p. 37 - 42
