N-甲基-4-哌啶甲酸甲酯合成路线 （共 23 条）
反应条件
formaldehyd; formic acid in water 3 h; Heating / reflux;
参考文献
BIOFOCUS PLC
Patent: WO2004/58259 A1, 2004 ;
Location in patent: Page/Page column 26-27 ;
反应条件
thionyl chloride in methanol
参考文献
Dynamac Corporaton
Patent: US4757079 A1, 1988 ;
反应条件
formic acid in formaldehyd; diethyl ether; water
参考文献
US5380731 A1, ;
US 5380731 A
反应条件
thionyl chloride T=-10 - 40°C; 3 h;
参考文献
Gray, Allan P.; Platz, Robert D.; Henderson, Theresa R.; Chang, Timothy C. P.; Takahashi, Kazuyuki; Dretchen, Kenneth L.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 4 p. 807 - 814
反应条件
methanol; nickel; triethylamine T=90°C; P=73550.8 Torr; Hydrogenation;
参考文献
Helvetica Chimica Acta, , vol. 37, p. 1672,1676
反应条件
1: platinum; aqueous acetic acid / 58840.6 Torr / Hydrogenation 2: palladium/charcoal; acetic acid / Hydrogenation View Scheme
参考文献
Journal of Organic Chemistry, , vol. 20, p. 1761,1765
反应条件
1: 94 percent / formic acid / 16 h / Heating 2: 87 percent / thionyl chloride / 3 h / -10 - 40 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 4 p. 807 - 814
反应条件
palladium on activated charcoal; acetic acid Hydrogenation;
参考文献
Journal of Organic Chemistry, , vol. 20, p. 1761,1765
Archiwum Chemji i Farmacji, , vol. 3, p. 109,113
Chem. Zentralbl., , vol. 108, # II p. 74
反应条件
methanol; platinum Hydrogenation;
参考文献
Journal of Organic Chemistry, , vol. 20, p. 1761,1765
Archiwum Chemji i Farmacji, , vol. 3, p. 109,113
Chem. Zentralbl., , vol. 108, # II p. 74
反应条件
T=150°C; im Rohr und Kochen des Reaktionsprodukts mit methylalkoholischer Salzsaeure;
参考文献
Chemische Berichte, , vol. 50, p. 386
Chemische Berichte, , vol. 52, p. 210
