(9ci)-1-(1-甲基乙基)-1H-吲哚合成路线 （共 10 条）
反应条件
2,6-di-tert-butyl-pyridine; copper(II) bis(trifluoromethanesulfonate) in dichloromethane T=35°C; 48 h;
参考文献
Kim, Aejin; Kim, In Su
Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 10 p. 3748 - 3751
反应条件
1: 2,6-di-tert-butyl-pyridine; copper(II) bis(trifluoromethanesulfonate) / dichloromethane / 48 h / 35 °C 2: trichlorophosphate / acetonitrile / 3 h / 80 °C View Scheme
参考文献
Kim, Aejin; Kim, In Su
Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 10 p. 3748 - 3751
反应条件
1: indole With sodium hydride in N,N-dimethyl-formamide; mineral oil
T=0 - 20°C;
2: 2-iodo-propane in N,N-dimethyl-formamide; mineral oil
T=20°C; 14 h;
参考文献
NANOTHERAPEUTICS, INC.; GHOSH, Shomir; GOLAN, Gali; INBAL, Boaz; JACQUES, Vincent; LOBERA, Mercedes
Patent: WO2010/65743 A2, 2010 ;
Location in patent: Page/Page column 32-33 ;
WO 2010/065743 A2
反应条件
(S)-dtbm-segphos; di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; ethyl acetate in octane
T=100°C; P=720 Torr; 24 h; Schlenk techniqueSealed tube;
参考文献
Sevov, Christo S.; Zhou, Jianrong; Hartwig, John F.
Journal of the American Chemical Society, 2014 , vol. 136, # 8 p. 3200 - 3207
反应条件
potassium hydroxide; PEG-400-Et2 in water; benzene
T=30°C; 3 h;
参考文献
Sukata, Kazuaki
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 1 p. 280 - 284
反应条件
methyl-magnesium iodide in various solvent(s)
1.) -6 deg C, 20 h, 2.) 22 deg C, 40 h; Title compound not separated from byproducts;
参考文献
Nilsson, Ingemar; Berg, Ulf; Sandstroem, Jan
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1984 , vol. 38, # 6 p. 491 - 500
反应条件
1.1: 3-chloro-benzenecarboperoxoic acid
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 1 h / 25 °C
2.2: 12 h / 25 °C
3.1: Raney nickel / ethanol / 5 h / Reflux
View Scheme
参考文献
Karchava; Shuleva; Ovcharenko; Yurovskaya
Chemistry of Heterocyclic Compounds, 2010 , vol. 46, # 3 p. 291 - 301
反应条件
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 1 h / 25 °C
1.2: 12 h / 25 °C
2.1: Raney nickel / ethanol / 5 h / Reflux
View Scheme
参考文献
Karchava; Shuleva; Ovcharenko; Yurovskaya
Chemistry of Heterocyclic Compounds, 2010 , vol. 46, # 3 p. 291 - 301
参考文献
Hegedus, Louis S.; Winton, Peter M.; Varaprath Sudarsanan
Journal of Organic Chemistry, 1981 , vol. 46, # 11 p. 2215 - 2221
反应条件
pyridinium chlorochromate in 1,2-dichloro-ethane
T=80°C; 2.5 h;
参考文献
Kumar, Chebolu Naga Sesha Sai Pavan; Devi, Chebrolu Lavanya; Rao, Vaidya Jayathirtha; Palaniappan, Srinivasan
Synlett, 2008 , # 13 p. 2023 - 2027
