5-甲基-3-苯基-4-异唑甲酰氯合成路线 （共 19 条）
反应条件
thionyl chloride 3 h; Heating / reflux;
参考文献
VIRONOVA AB; HOMMAN, Mohammed; KINGI, Ngarita; BERGMAN, Jan; ENGQVIST, Robert
Patent: WO2013/171334 A1, 2013 ;
Location in patent: Page/Page column 23 ;
反应条件
pyridine; thionyl chloride
反应条件
1: water; sodium hydroxide / methanol / 1 h / pH 11 - 13 / Reflux 2: phosphorus pentachloride / 1 h / 45 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 49, # 3 p. 621 - 627
反应条件
1.1: hydroxylammonium sulfate / methanol / 0.5 h 1.2: 0.5 h / pH 8 - 9 / Reflux 2.1: chlorine / methanol / 0 - 5 °C 3.1: sodium hydroxide / methanol / 0.5 h / 0 - 5 °C / pH 10 3.2: 2 h / 0 - 20 °C / pH 9 4.1: water; sodium hydroxide / methanol / 1 h / pH 11 - 13 / Reflux 5.1: phosphorus pentachloride / 1 h / 45 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 49, # 3 p. 621 - 627
反应条件
1.1: sodium hydroxide / methanol / 0.5 h / 0 - 5 °C / pH 10 1.2: 2 h / 0 - 20 °C / pH 9 2.1: water; sodium hydroxide / methanol / 1 h / pH 11 - 13 / Reflux 3.1: phosphorus pentachloride / 1 h / 45 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 49, # 3 p. 621 - 627
反应条件
1.1: chlorine / methanol / 0 - 5 °C 2.1: sodium hydroxide / methanol / 0.5 h / 0 - 5 °C / pH 10 2.2: 2 h / 0 - 20 °C / pH 9 3.1: water; sodium hydroxide / methanol / 1 h / pH 11 - 13 / Reflux 4.1: phosphorus pentachloride / 1 h / 45 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 49, # 3 p. 621 - 627
反应条件
pyridine in 1,4-dioxane T=0 - 20°C;
参考文献
VIRONOVA AB; HOMMAN, Mohammed; KINGI, Ngarita; BERGMAN, Jan; ENGQVIST, Robert
Patent: WO2013/171334 A1, 2013 ;
Location in patent: Page/Page column 23 ;
反应条件
Friedel-Crafts reaction conditions;
参考文献
Shamshin; Aleshina; Sukhanova; Kabanova
Pharmaceutical Chemistry Journal, 2001 , vol. 35, # 7 p. 349 - 352
反应条件
1: NaN3 / acetone; H2O / 16 h 2: 230 mg / 1,2-dichloro-ethane / 0.75 h / 110 °C View Scheme
参考文献
Tucker, John A.; Clayton, Terrance L.; Chidester, Connie G.; Schulz, Martin W.; Harrington, Leigh E.; Conrad, Steven J.; Yagi, Yoshihiko; Oien, Nancee L.; Yurek, David; Kuo, Ming-Shang
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 3 p. 601 - 615
反应条件
1: With triethylamine in dichloromethane T=20°C; 0.5 h; 2: With hydrogenchloride in water
参考文献
Nottingham, Micheal; Bethel, Christopher R.; Pagadala, Sundar Ram Reddy; Harry, Emily; Pinto, Abishai; Lemons, Zachary A.; Drawz, Sarah M.; Akker, Focco Van Den; Carey, Paul R.; Bonomo, Robert A.; Buynak, John D.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 387 - 393
