2,5,6-三氯苯并咪唑合成路线 （共 10 条）
反应条件
1: With trichlorophosphate 3 h; Reflux; 2: With sodium hydroxide in water T=20°C; pH=7.0;
参考文献
JANSSEN PHARMACEUTICA NV
Patent: WO2009/134750 A1, 2009 ;
Location in patent: Page/Page column 60 ;
反应条件
1: in tetrahydrofuran T=20°C; 16 h; 2: With trichlorophosphate T=120°C; 2 h;
参考文献
US2005/54628 A1, ;
Page/Page column 31 ;
US 20050054628 A1
反应条件
copper dichloride; sodium nitrite 1.) RT, 2 h, 2.) H2O, 100 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 20 p. 4098 - 4105
反应条件
phosphorus pentachloride; trichlorophosphate in tetrahydrofuran
反应条件
1: 0.5 h / 150 °C 2: POCl3, HCl / 3 h / 150 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 4 p. 586 - 593
反应条件
phosphorus pentachloride in trichlorophosphate 6 h; Heating;
参考文献
Hinkley, Jack M.; Porcari, Anthony R.; Walker II, John A.; Swayze, Eric E.; Townsend, Leroy B.
Synthetic Communications, 1998 , vol. 28, # 9 p. 1703 - 1712
反应条件
1: 92 percent / NaCO3*1.5H2O2 / H2O / 4 h / Heating 2: 82 percent / PCl5 / POCl3 / 6 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 28, # 9 p. 1703 - 1712
反应条件
in methanol; hexane; chloroform; ethyl acetate; acetonitrile
参考文献
The Regents of the University of Michigan
Patent: US5248672 A1, 1993 ;
反应条件
in methanol; hexane; chloroform; ethyl acetate; acetonitrile
参考文献
The Regents of the University of Michigan
Patent: US5574058 A1, 1996 ;
反应条件
1: acetonitrile / 0.33 h / 75 °C
2: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 16 h / Ambient temperature
3: 74 percent / methanolic ammonia / Ambient temperature
View Scheme
参考文献
Townsend, Leroy B.; Devivar, Rodrigo V.; Turk, Steven R.; Nassiri, M. Reza; Drach, John C.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 20 p. 4098 - 4105
