3-(2-噻吩)丙酸甲酯合成路线 （共 15 条）
反应条件
1.1: sodium hydroxide / water; tetrahydrofuran / 3 h / |Reflux 1.2: 20 °C 2.1: polyphosphoric acid / chlorobenzene / 0.38 h / 130 °C / |Inert atmosphere View Scheme
参考文献
MacHara, Ales; Svoboda, Jiri
Chemical Papers, 2013 , vol. 67, # 1 p. 59 - 65,7
反应条件
1: 1.) LDA / 1.) THF, hexane, -78 deg C, 60 min, 2.) THF, hexane, -78 deg C, 10 min 2: (dimethylamino)pyridine / CH2Cl2 / 19 h 3: DBU / toluene / 1 h / 100 °C 4: 70 percent / 10percent aq. NaOH / ethanol / 17 h / Ambient temperature View Scheme
参考文献
Weinstock, Joseph; Keenan, Richard M.; Samanen, James; Hempel, Judith; Finkelstein, Joseph A.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1514 - 1517
反应条件
1: 1.) LDA / 1.) THF, hexane, -78 deg C, 60 min, 2.) THF, hexane, -78 deg C, 10 min 2: (dimethylamino)pyridine / CH2Cl2 / 19 h 3: DBU / toluene / 1 h / 100 °C View Scheme
参考文献
Keenan, Richard M.; Weinstock, Joseph; Finkelstein, Joseph A.; Franz, Robert G.; Gaitanopoulos, Dimitri E.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 13 p. 1880 - 1892
反应条件
diisobutylaluminium hydride in diethyl ether; toluene T=-78°C; 1 h;
参考文献
Carroll, F. Ivy; Melvin, Matt S.; Nuckols, Michel C.; Mascarella, S. Wayne; Navarro, Hernan A.; Thomas, James B.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1781 - 1791
反应条件
1: 92 percent / diisobutylaluminum hydride / diethyl ether; toluene / 1 h / -78 °C
2: 83 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / -78 - 20 °C
View Scheme
参考文献
Carroll, F. Ivy; Melvin, Matt S.; Nuckols, Michel C.; Mascarella, S. Wayne; Navarro, Hernan A.; Thomas, James B.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1781 - 1791
