2-甲基吡啶-4-羧酸甲酯合成路线 （共 18 条）
反应条件
sodium hydroxide; palladium in methanol
参考文献
Zeneca Limited; Zeneca Pharma S. A.
Patent: US6362336 B1, 2002 ;
Location in patent: Example 63 ;
US 6362336 B1
反应条件
sulfuric acid 4 h; Reflux;
参考文献
AMGEN INC.; DU, Xiaohui; FU, Zice; HOUZE, Jonathan, B.; JIAO, Xianyun; KIM, Yong-jae; LI, Leping; LIU, Jinqian; LIZARZABURU, Mike; MEDINA, Julio; SHEN, Wang; TURCOTTE, Simon; YU, Ming
Patent: WO2010/93849 A2, 2010 ;
Location in patent: Page/Page column 68; 69 ;
WO 2010/093849 A2
反应条件
triethylamine; Pd(0)(dppf)2 in methanol; N,N-dimethyl-formamide T=75°C; Inert atmosphere;
参考文献
WO2011/38086 A2, ;
Page/Page column 85-86 ;
WO 2011/038086 A2
反应条件
thionyl chloride in methanol; water
参考文献
SmithKline Beecham Corporation
Patent: US5686455 A1, 1997 ;
反应条件
1: 2-methyl-nicotinic acid ; hydrochloride With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=0 - 20°C; 2: methanol in tetrahydrofuran T=0°C; 1 h;
参考文献
WO2004/14881 A2, ;
Page 138-139 ;
WO 2004/014881 A2
反应条件
1: With ozone in methanol; dichloromethane T=-78°C; 2: With triphenylphosphine in methanol; dichloromethane T=-78 - 20°C; 3: With ammonia in methanol; ethanol; dichloromethane T=20°C;
参考文献
Craig, Donald; Henry, Gavin D.
Tetrahedron Letters, 2005 , vol. 46, # 15 p. 2559 - 2562
反应条件
thionyl chloride T=5 - 65°C; 1 h;
参考文献
US2006/100440 A1, ;
Page/Page column 4 ;
反应条件
1: POCl3; PCl5 2: palladium/charcoal; aq.-ethanolic HCl / Hydrogenation View Scheme
参考文献
Journal of the American Chemical Society, , vol. 81, p. 704,707
反应条件
1: POCl3; PCl5 / Behandeln des Reaktionsprodukts mit Methanol 2: palladium/charcoal; methanol; potassium acetate / Hydrogenation View Scheme
参考文献
Helvetica Chimica Acta, , vol. 38, p. 1046,1058
Bulletin de la Societe Chimique de France, , p. 687,691
反应条件
1: aqueous KMnO4 2: concentrated H2SO4 View Scheme
参考文献
Bulletin de la Societe Chimique de France, , p. 648
