4-氨基-2,3,5,6-四氟吡啶合成路线 （共 43 条）
反应条件
in dimethyl sulfoxide T=25°C; Equilibrium constant;
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 25, # 11.1 p. 2041 - 2044
Zhurnal Organicheskoi Khimii, , vol. 25, # 11 p. 2261 - 2265
反应条件
in dimethyl sulfoxide T=25°C; Equilibrium constant;
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 25, # 11.1 p. 2041 - 2044
Zhurnal Organicheskoi Khimii, , vol. 25, # 11 p. 2261 - 2265
反应条件
hydrazine in ethanol 24 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 2 p. 340 - 347
反应条件
1: 69.5 percent / H2NNH2 / ethanol / 24 h / Heating 2: 56 percent / aq. CuSO4 / 48 h / Ambient temperature 3: 82.1 percent / 2N aq. NaOH / 24 h / Heating View Scheme
参考文献
McNamara; Cook
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 340 - 347
反应条件
in hydrogen fluoride; hydrogen bromide Diazotation with NaNO2 in 20 percent aq. HF at - 20 °C (0.5 h). Cleavage by dropwise addn. of CuBr in 48 percent aq. HBr at -20 to -25 °C (0.5 h).;
参考文献
Gmelin Handbook: F: PerFHalOrg.5, 4, page 115 - 148
反应条件
in dimethyl sulfoxide T=25°C; Equilibrium constant;
参考文献
Os'kina, I. A.; Vlasov, V. M.; Terekhova, M. I.; Petrov, E. S.
Journal of Organic Chemistry USSR (English Translation), 1989 , vol. 25, # 11.1 p. 2041 - 2044
Zhurnal Organicheskoi Khimii, 1989 , vol. 25, # 11 p. 2261 - 2265
反应条件
1: 69.5 percent / H2NNH2 / ethanol / 24 h / Heating 2: 56 percent / aq. CuSO4 / 48 h / Ambient temperature View Scheme
参考文献
McNamara; Cook
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 340 - 347
反应条件
in dimethyl sulfoxide
T=25°C; Equilibrium constant;
参考文献
Os'kina, I. A.; Vlasov, V. M.; Terekhova, M. I.; Petrov, E. S.
Journal of Organic Chemistry USSR (English Translation), 1989 , vol. 25, # 11.1 p. 2041 - 2044
Zhurnal Organicheskoi Khimii, 1989 , vol. 25, # 11 p. 2261 - 2265
反应条件
sodium nitrite in hydrogen fluoride
Ambient temperature;
参考文献
Alty, Adam C.; Banks, Ronald E.; Thompson, A. Ronald; Vellis, Haralambos S.; Fishwick Brian R.
Journal of Fluorine Chemistry, 1988 , vol. 40, p. 147 - 170
反应条件
1: NaNO2, aq. HF / 0.25 h / -20 °C
2: aq. HF / 1 h / -50 °C
View Scheme
参考文献
Banks, Ronald E.; Thompson, A. Ronald; Vellis, Haralambos S.
Journal of Fluorine Chemistry, 1983 , vol. 22, p. 499 - 501
