4-羟基-N-甲基-2-喹啉合成路线 （共 65 条）
反应条件
1: 90 percent / conc. HNO3, NaNO2 / acetic acid / 0.5 h 2: 92 percent / triethylamine, phosphoryl chloride / 1 h / Heating 3: 96 percent / various solvent(s) / Ambient temperature View Scheme
参考文献
Roschger, Peter; Fiala, Werner; Stadlbauer, Wolfgang
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 1 p. 225 - 231
反应条件
1: 82 percent / phosphorus oxychloride / dioxane / 0.42 h / 120 °C / microwave irradiation
2: 83 percent / triethylamine; PPh3 / Pd(OAc)2 / 1,2-dimethoxy-ethane; H2O / 0.5 h / 150 °C / microwave irradiation
View Scheme
参考文献
Glasnov, Toma N.; Stadlbauer, Wolfgang; Kappe, C. Oliver
Journal of Organic Chemistry, 2005 , vol. 70, # 10 p. 3864 - 3870
反应条件
1: 90 percent / aq. Na2CO3 / 24 h
2: 94 percent / AlCl3 / 1 h / 130 - 140 °C
View Scheme
参考文献
Kappe, Thomas; Schnell, Barbara
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 3 p. 663 - 670
反应条件
1: AcOH / aq. ethanol / Heating
2: AcOH / Heating
View Scheme
参考文献
Mazzei; Roma; Ermili
Journal of Heterocyclic Chemistry, 1978 , vol. 15, # 4 p. 605 - 608
反应条件
1: 91 percent / NBS; Mg(ClO4)2 / acetonitrile
2: 86 percent / Et3N
3: 81 percent / Na2CO3 / PdCl2(PPh3)2 / tetrahydrofuran; H2O / 20 °C
View Scheme
参考文献
Wu, Jie; Zhang, Liang; Sun, Xiaoyu
Chemistry Letters, 2005 , vol. 34, # 4 p. 550 - 551
反应条件
1: 92 percent / potassium carbonate / dimethylformamide / 5 h / 100 - 130 °C
2: 97 percent / hydrogen peroxide / aq. NaOH / 2 h / 20 °C
View Scheme
参考文献
Schnell, Barbara; Kappe, Thomas
Monatshefte fur Chemie, 1999 , vol. 130, # 9 p. 1147 - 1157
反应条件
1: nitric acid / acetic acid / 90 °C
2: triethylamine / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice
View Scheme
参考文献
Audisio, Davide; Messaoudi, Samir; Cojean, Sandrine; Peyrat, Jean-Francois; Brion, Jean-Daniel; Bories, Christian; Huteau, Francoise; Loiseau, Philippe M.; Alami, Mouad
European Journal of Medicinal Chemistry, 2012 , vol. 52, p. 44 - 50
反应条件
1: 62 percent / ethane-1,2-diol / 190 °C
2: 81 percent / 2 N aq. NaOH / dioxane / 2 h / 100 °C
3: 48 percent / POCl3 / 16 h / Heating
4: 90 percent / H2SO4 / 2 h / 70 °C
View Scheme
参考文献
Roschger, Peter; Stadlbauer, Wolfgang
Liebigs Annalen der Chemie, 1991 , # 4 p. 401 - 403
反应条件
thionyl chloride
2 h; Ambient temperature;
参考文献
Khan, Khalid A.; Shoeb, Aboo
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 62 - 66
反应条件
1: 90 percent / mesyl azide; triethylamine / ethanol / 12 h / 20 °C
2: 12 percent / rhodium(II) pivalate / fluorobenzene / 55 °C
3: 61 percent / TBAF / tetrahydrofuran / 0.17 h
View Scheme
参考文献
Pirrung, Michael C.; Blume, Florian
Journal of Organic Chemistry, 1999 , vol. 64, # 10 p. 3642 - 3649
