反应条件
1: 77 percent / LDA / hexane; tetrahydrofuran / 1.) -78 to 0 deg C, 45 min; 25 deg C, 3 h, 2.) -78 deg C, 5 min; -78 to 0 deg C
2: 98 percent / Br2 / CH2Cl2; CCl4 / 3 h / 25 °C
3: 99 percent / NaH / tetrahydrofuran; paraffin / 1.) 0 deg C, 10 min; 0 to 25 deg C, 10 min, 2.) reflux, 2 h
4: 85 percent / p-TsOH, molecular sieves 4 Angstroem / toluene / 4 h / Heating
5: 48 percent / n-BuLi / tetrahydrofuran; hexane / 1.) 0 deg C, 10 min, 2.) reflux, 3 h
View Scheme
参考文献
Love, Brian E.; Raje, Prasad S.
Journal of Organic Chemistry, 1994 , vol. 59, # 11 p. 3219 - 3222
