(±)-2-氯-1-苯基乙醇合成路线 （共 94 条）
反应条件
1: With sodium hexamethyldisilazane in tetrahydrofuran T=0 - 25°C; 2: With water in tetrahydrofuran T=25°C; 5 h; regioselective reaction;
参考文献
Murugan, Andiappan; Kadambar, Vasantha Krishna; Bachu, Sreekanth; Rajashekher Reddy; Torlikonda, Venkatarao; Manjunatha, Sulur G.; Ramasubramanian, Sridharan; Nambiar, Sudhir; Howell, Gareth P.; Withnall, Jane
Tetrahedron Letters, 2012 , vol. 53, # 43 p. 5739 - 5741
反应条件
potassium carbonate; palladium diacetate; tris-(o-tolyl)phosphine in toluene T=100°C; 3 h;
参考文献
Tetrahedron Letters, , vol. 23, # 30 p. 3085 - 3088
参考文献
Schallmey, Marcus; Floor, Robert J.; Hauer, Bernhard; Breuer, Michael; Jekel, Peter A.; Wijma, Hein J.; Dijkstra, Bauke W.; Janssen, Dick B.
ChemBioChem, 2013 , vol. 14, # 7 p. 870 - 881
参考文献
Spaeth
Monatshefte fuer Chemie, 1915 , vol. 36, p. 6
反应条件
N-iodo-succinimide; potassium carbonate in ethyl acetate T=20°C; Inert atmosphereMolecular sieve;
参考文献
Temperini, Andrea; Annesi, Diego; Testaferri, Lorenzo; Tiecco, Marcello
Tetrahedron Letters, 2011 , vol. 52, # 25 p. 3179 - 3182
反应条件
1: 1.) n-BuLi, 2.) lithium naphthalenide
2: diethyl ether
View Scheme
参考文献
Barluenga, Jose; Florez, Josefa; Yus, Miguel
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 3019 - 3026
反应条件
n-butyllithium; naphthalenyllithium in tetrahydrofuran; diethyl ether
-78 deg C, 2 h; to 20 deg C, overnight;
参考文献
Barluenga, Jose; Florez, Josefa; Yus, Miguel
Journal of the Chemical Society, Chemical Communications, 1982 , # 20 p. 1153 - 1154
参考文献
Kanao; Shinozuka
Yakugaku Zasshi, 1948 , vol. 68, p. 70
Chem.Abstr., 1950 , p. 1054
反应条件
1: methanol. KOH
View Scheme
参考文献
Emerson
Journal of the American Chemical Society, 1945 , vol. 67, p. 516
反应条件
sodium hydride in N,N-dimethyl-formamide
参考文献
Matsuda, Takumi; Yamagata, Kenji; Tomioka, Yukihiko; Yamazaki, Motoyoshi
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 937 - 943
