反应条件
1: NaOMe / methanol / 36 h / Heating
2: H2 / Pd(OH)2/C / methanol; tetrahydrofuran / 24 h / 20 °C / 2844.31 Torr
3: 21.90 g / K2CO3 / dimethylformamide / 20 °C
4: 71 percent / pyridine tribromide / tetrahydrofuran; CHCl3 / 2.5 h / 0 - 20 °C
5: 88 percent / LiCl; Na2CO3; Pd(PPh3)4 / toluene; ethanol; H2O / 80 °C
View Scheme
参考文献
Beaulieu, Pierre L.; Gillard, James; Bykowski, Darren; Brochu, Christian; Dansereau, Nathalie; Duceppe, Jean-Simon; Hache, Bruno; Jakalian, Araz; Lagace, Lisette; LaPlante, Steven; McKercher, Ginette; Moreau, Elaine; Perreault, Stephane; Stammers, Timothy; Thauvette, Louise; Warrington, Jeff; Kukolj, George
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 19 p. 4987 - 4993