4-(2-哌啶乙氧基)苯甲酸盐酸盐合成路线 （共 9 条）
反应条件
thionyl chloride in tetrahydrofuran T=20 - 50°C;
参考文献
WO2006/34090 A1, ;
Page/Page column 104-105 ;
反应条件
thionyl chloride; N,N-dimethyl-formamide in toluene
参考文献
Journal of Medicinal Chemistry, , vol. 27, # 8 p. 1057 - 1066
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 17 h / 100 °C 2: sodium hydroxide / methanol / 15 h / 20 °C 3: thionyl chloride / Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 16 p. 5722 - 5736
反应条件
1: sodium hydroxide / methanol / 15 h / 20 °C 2: thionyl chloride / Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 16 p. 5722 - 5736
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 17 h / 100 °C 2: sodium hydroxide / methanol / 15 h / 20 °C 3: thionyl chloride / Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 16 p. 5722 - 5736
反应条件
aluminium trichloride; sodium carbonate; 1,2-dichloro-ethane in water; ethyl acetate
参考文献
Eli Lilly and Company
Patent: US6124311 A1, 2000 ;
反应条件
1: 93 percent / trifluoromethanesulfonic acid / 1,2-dichloro-ethane / Heating 2: 42 percent / 5 N aq. NaOH / ethanol / 1.5 h / Heating View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: AlCl3 / CH2Cl2 / 1.5 h / 27 - 29 °C 2: 77.5 percent / AlCl3, EtSH / CH2Cl2 / 0.5 h / Ambient temperature View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
aluminium trichloride in dichloromethane
T=27 - 29°C; 1.5 h; Yield given;
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
