4-氨基-1,3-苯并二恶茂合成路线 （共 14 条）
反应条件
hydrogenchloride in 1,4-dioxane T=18 - 22°C; 1 h;
参考文献
WO2004/103996 A1, ;
Page 50 ;
WO 2004/103996 A1
反应条件
hydrazine hydrate in methanol T=0°C;
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 19 p. 4128 - 4139
反应条件
palladium 10 on activated carbon; hydrogen in ethyl acetate P=1551.49 Torr; 6 h;
参考文献
Journal of Medicinal Chemistry, , vol. 52, # 7 p. 1873 - 1884
反应条件
sulfuric acid; hydroxylamine-o-sulphonic acid; iron(II) sulfate in water; N,N-dimethyl-formamide T=30 - 35°C; 1 h; Yield given. Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 49, # 23 p. 4479 - 4482
反应条件
1: 40 percent / K2CO3; tetrabutylammonium bromide / toluene / 24 h / Heating 2: 90 percent / Ni-Ra; hydrazine monohydrate / methanol / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 19 p. 4128 - 4139
反应条件
1: 77 percent / DPPA; Et3N / dioxane / 5 h / Heating 2: 91 percent / aq. HCl / ethanol / 20 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 4 p. 871 - 887
反应条件
1: 73 percent / KOH / methanol; H2O / 2 h / 20 °C 2: 77 percent / DPPA; Et3N / dioxane / 5 h / Heating 3: 91 percent / aq. HCl / ethanol / 20 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 4 p. 871 - 887
反应条件
1.1: 40 percent / H2SO4 / 24 h / 60 °C 2.1: KF / dimethylformamide / 0.5 h / 20 °C 2.2: 80 percent / dimethylformamide / 3 h / 120 °C 3.1: 73 percent / KOH / methanol; H2O / 2 h / 20 °C 4.1: 77 percent / DPPA; Et3N / dioxane / 5 h / Heating 5.1: 91 percent / aq. HCl / ethanol / 20 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 4 p. 871 - 887
反应条件
1.1: nitric acid / diethyl ether / 0.33 h / 0 - 20 °C 2.1: sodium hydride / N,N,N',N',N'',N''-hexamethylphosphoric triamide / 0.17 h 2.2: 0.5 h 3.1: hydrogen / Raney Ni / ethanol / 4 h View Scheme
参考文献
WO2012/92880 A1, ;
WO 2012/092880 A1
参考文献
Agricultural and Biological Chemistry, , vol. 44, # 2 p. 235 - 243
