反应条件
1: 2.) Et3N / 1.) CH2Cl2, 0 deg C, 2.) 45 min
2: 100 percent / HCl gas / ethyl acetate / 0.05 h / 0 °C
3: 72 percent / Na(OAc)3BH, 4A MS / 1,2-dichloro-ethane / 4 h / 0 - 20 °C / tandem reductive alkylation-cyclization of amines with various aldehydes and ketones to give 2m3-diketopiperazines
4: 81 percent / aq. HCl / 5 h / Heating
View Scheme
参考文献
Bhatia, Pramila A.; Brooks, Clint D. W.; Basha, Anwer; Ratajczyk, James D.; Gunn, Bruce P.; Bouska, Jennifer B.; Lanni, Carmine; Young, Patrick R.; Bell, Randy L.; Carter, George W.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 20 p. 3938 - 3950
