4,4'-di-tert-butylbiphenyl; lithium in tetrahydrofuran T=20°C; 2 h;

1.1: tetrahydrofuran / 0.5 h / -78 °C 2.1: tetrahydrofuran / 0.5 h / 25 °C 3.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / 15 - 25 °C / |Large scale 3.2: 1.5 h / 20 - 30 °C / |Large scale 4.1: 1,1,1,3,3,3-hexamethyl-disilazane / anhydrous xylene / 12 h / 80 - 165 °C / |Large scale View Scheme

in tetrahydrofuran T=60°C; 6 h; Inert atmosphereFlow reactor;