5-硝基-6-甲基-脲嘧啶合成路线 （共 27 条）
反应条件
tetraethylammonium chloride; 2,3-dimethyl aniline; trichlorophosphate in acetonitrile
参考文献
Chen; Adrian; Cushing; DiMaio; Liang; Mayorga; Miao; Peterson; Powers; Spector; Stein; Wright; Xu; Ye; Jaen
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 8 p. 2188 - 2192
参考文献
Marshall; Walker
Journal of the Chemical Society, 1951 , p. 1004,1015
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, vol. 24, p. 84
反应条件
T=150 - 160°C; im Rohr;
参考文献
Gabriel; Colman
Chemische Berichte, 1901 , vol. 34, p. 1242
反应条件
nitric acid T=100°C; 4 h;
参考文献
Boyle, Peter H.; Gillespie, Paul
Journal of Chemical Research, Miniprint, 1989 , # 9 p. 2086 - 2097
反应条件
1: 81.2 percent / dimethylformamide / 0.5 h / 130 - 135 °C 2: 82.46 percent / Zn, acetic acid / 1 h / 70 - 80 °C 3: 60.6 percent / POCl3 / 6 h / Heating 4: 18 percent / POCl3, diethylaniline / 40 h / Heating 5: 85.2 percent / ethanol / 8.5 h / Heating View Scheme
参考文献
Modnikova, G. A.; Titkova, R. M.; Glushkov, R. G.; Sokolova, A. S.; Silin, V. A.; Chernov, V. A.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 2 p. 135 - 141
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 2 p. 185 - 191
反应条件
1: 81.2 percent / dimethylformamide / 0.5 h / 130 - 135 °C 2: 82.46 percent / Zn, acetic acid / 1 h / 70 - 80 °C 3: 60.6 percent / POCl3 / 6 h / Heating 4: 18 percent / POCl3, diethylaniline / 40 h / Heating 5: 80.2 percent / ethanol / 5 h / Heating View Scheme
参考文献
Modnikova, G. A.; Titkova, R. M.; Glushkov, R. G.; Sokolova, A. S.; Silin, V. A.; Chernov, V. A.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 2 p. 135 - 141
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 2 p. 185 - 191
反应条件
1: 81.2 percent / dimethylformamide / 0.5 h / 130 - 135 °C 2: 82.46 percent / Zn, acetic acid / 1 h / 70 - 80 °C 3: 60.6 percent / POCl3 / 6 h / Heating 4: 18 percent / POCl3, diethylaniline / 40 h / Heating 5: 66.3 percent / potassium carbonate / aq. ethanol / 9 h / Heating View Scheme
参考文献
Modnikova, G. A.; Titkova, R. M.; Glushkov, R. G.; Sokolova, A. S.; Silin, V. A.; Chernov, V. A.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 2 p. 135 - 141
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 2 p. 185 - 191
反应条件
1: 81.2 percent / dimethylformamide / 0.5 h / 130 - 135 °C 2: 82.46 percent / Zn, acetic acid / 1 h / 70 - 80 °C 3: 60.6 percent / POCl3 / 6 h / Heating 4: 18 percent / POCl3, diethylaniline / 40 h / Heating 5: 73.25 percent / potassium carbonate / H2O / 4 h / Heating View Scheme
参考文献
Modnikova, G. A.; Titkova, R. M.; Glushkov, R. G.; Sokolova, A. S.; Silin, V. A.; Chernov, V. A.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 2 p. 135 - 141
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 2 p. 185 - 191
反应条件
1: 81.2 percent / dimethylformamide / 0.5 h / 130 - 135 °C 2: 82.46 percent / Zn, acetic acid / 1 h / 70 - 80 °C 3: 60.6 percent / POCl3 / 6 h / Heating 4: 18 percent / POCl3, diethylaniline / 40 h / Heating 5: potassium carbonate / aq. ethanol / 4 h / Heating View Scheme
参考文献
Modnikova, G. A.; Titkova, R. M.; Glushkov, R. G.; Sokolova, A. S.; Silin, V. A.; Chernov, V. A.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 2 p. 135 - 141
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 2 p. 185 - 191
反应条件
1: 81.2 percent / dimethylformamide / 0.5 h / 130 - 135 °C
2: 82.46 percent / Zn, acetic acid / 1 h / 70 - 80 °C
3: 60.6 percent / POCl3 / 6 h / Heating
4: 18 percent / POCl3, diethylaniline / 40 h / Heating
5: 81.9 percent / potassium carbonate / aq. ethanol / 13 h / Heating
View Scheme
参考文献
Modnikova, G. A.; Titkova, R. M.; Glushkov, R. G.; Sokolova, A. S.; Silin, V. A.; Chernov, V. A.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 2 p. 135 - 141
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 2 p. 185 - 191
