2',3'-O-(甲氧基亚甲基)尿苷合成路线 （共 7 条）
反应条件
NOBF4 in acetonitrile
参考文献
Owen,G.R. et al.
Journal of Organic Chemistry, 1976 , vol. 41, p. 3010 - 3017
反应条件
1: 690 mg / N-methylimidazole; pyridine / tetrahydrofuran / 20 °C 2: LiHMDS / tetrahydrofuran / 2 h / -78 - 0 °C 3: 215 mg / aq. HCl / acetonitrile / 4 h / 20 °C / pH 2.0 4: H2 / Pd/C / tetrahydrofuran / 2 h / 20 °C 5: 45 mg / tris(tetra-n-butylammonium) hydrogen pyrophosphate / tetrahydrofuran / 0.5 h / 20 °C View Scheme
参考文献
Wu, Weidong; Meyers, Caren L. Freel; Borch, Richard F.
Organic Letters, 2004 , vol. 6, # 13 p. 2257 - 2260
反应条件
1: 4-(N,N-dimethylamino)pyridine (4-DMAP) / CH2Cl2 / 24 h 2: 87 percent / aq. HCl / acetonitrile / 1 h 3: 58 percent / acetonitrile / 48 h View Scheme
参考文献
Davisson, V. Jo; Davis, Darrell R.; Dixit, Vyas M.; Poulter, C. Dale
Journal of Organic Chemistry, 1987 , vol. 52, # 9 p. 1794 - 1801
反应条件
1: 42 percent / 3 h / 132 °C 2: 43 percent / 29percent NH4OH / methanol / 12 h / Ambient temperature 3: 97 percent / H2 / 5percent Pd/C / methanol / 1 h View Scheme
参考文献
Shiragami; Irie; Shirae; Yokozeki; Yasuda
Journal of Organic Chemistry, 1988 , vol. 53, # 21 p. 5170 - 5173
反应条件
1: pyridine / dioxane / 0.17 h
2: bis(tri-n-butylammonium) pyrophosphate, tri-n-butylamine / dimethylformamide / 0.17 h
3: sulfur / dimethylformamide / 0.17 h
4: 1.) H2O, 2.) glacial acetic acid / 1.) 30 min, 2.) room temp., 1 h
View Scheme
参考文献
Ludwig, Janos; Eckstein, Fritz
Journal of Organic Chemistry, 1989 , vol. 54, # 3 p. 631 - 635
反应条件
acetic anhydride in water
参考文献
Ajinomoto Co., Inc.
Patent: US4962193 A1, 1990 ;
反应条件
1: 42 percent / 3 h / 132 °C
2: 43 percent / 29percent NH4OH / methanol / 12 h / Ambient temperature
View Scheme
参考文献
Mansuri; Starrett Jr.; Wos; Tortolani; Brodfuehrer; Howell; Martin
Journal of Organic Chemistry, 1989 , vol. 54, # 20 p. 4780 - 4785
