4-氯-3-硝基苯甲酰胺合成路线 （共 12 条）
反应条件
1: With N,N-dimethyl-formamide in thionyl chloride 1 h; Heating / reflux; 2: With ammonia in tetrahydrofuran; thionyl chloride; water 1 h;
参考文献
Shionogi and Co., Ltd.
Patent: WO2005/121132 A1, 2005 ;
Location in patent: Page/Page column 249-250 ;
反应条件
tetrachloromethane; ammonium hydroxide
参考文献
Journal of the Chemical Society, , p. 1672,1676
反应条件
dihydrogen peroxide; potassium carbonate in water; dimethyl sulfoxide T=60°C;
参考文献
Hwang, Jong Yeon; Attia, Ramy R.; Zhu, Fangyi; Yang, Lei; Lemoff, Andrew; Jeffries, Cynthia; Connelly, Michele C.; Guy, R. Kiplin
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2301 - 2310
反应条件
thionyl chloride in ethanol; water; acetonitrile
反应条件
triethylamine in dichloromethane T=20°C; 4 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 22 p. 6419 - 6423
反应条件
tetramethyl-ammonium fluoride in dimethyl sulfoxide T=100°C; Substitution; 1 h; Further byproducts given;
参考文献
Journal of Fluorine Chemistry, , vol. 94, # 1 p. 51 - 55
反应条件
1: bei der Nitrierung 2: PCl5 3: diethyl ether; aqueous ammonia View Scheme
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 19, p. 55
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 19, p. 55
反应条件
methanol; palladium on activated charcoal Hydrogenation;
参考文献
Foye; Stoyle
Journal of the American Pharmaceutical Association (1912-1977), 1959 , vol. 48, p. 201
反应条件
MeSO3SiMe3; phosphorus pentoxide T=70 - 75°C; 3 h; further reagents;
参考文献
Rao, C. Someswara; Rambabu, M.; Srinivasan, P. S.
Synthetic Communications, 1989 , vol. 19, # 7,8 p. 1431 - 1436
