1: bromobenzene With magnesium in tetrahydrofuran
Inert atmosphere;
2: isoquinoline-1 -carbonitrile in tetrahydrofuran; toluene
T=0 - 20°C; Inert atmosphere;
3: With hydrogenchloride; water in diethyl ether
0.333333 h; Inert atmosphere;
参考文献
Reux, Bastien; Nevalainen, Tapio; Raitio, Katri H.; Koskinen, Ari M.P.
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 13 p. 4441 - 4447