3-(4-甲基-1,3-噻唑-5-基)丙醛合成路线 （共 3 条）
反应条件
diisobutylaluminium hydride in toluene T=21°C; 1 h;
参考文献
Sawyer, David A.; Beams, Richard M.; Blackwell, Geoffrey, J.; Brockwell, Michael A.; Cheesman, Neil J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2130 - 2137
反应条件
1: CH2Cl2 / 1.) from -10 deg C to 0 deg C, 2h, 2.) 21 deg C, 2 h 2: 18-crown-6 / dimethylformamide / 1.) 21 deg C, 16 h, 2.) 80 deg C, 1 h 3: 36 g / diisobutylaluminum hydride / toluene / 1 h / 21 °C View Scheme
参考文献
Sawyer, David A.; Beams, Richard M.; Blackwell, Geoffrey, J.; Brockwell, Michael A.; Cheesman, Neil J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2130 - 2137
反应条件
1: 18-crown-6 / dimethylformamide / 1.) 21 deg C, 16 h, 2.) 80 deg C, 1 h 2: 36 g / diisobutylaluminum hydride / toluene / 1 h / 21 °C View Scheme
参考文献
Sawyer, David A.; Beams, Richard M.; Blackwell, Geoffrey, J.; Brockwell, Michael A.; Cheesman, Neil J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2130 - 2137
