2-甲氧基-6-硝基苯胺合成路线 （共 28 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide 14 h;
参考文献
MERCK SHARP and DOHME CORP.; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.R.L.; MCCAULEY, John, A.; LIVERTON, Nigel, J.; RUDD, Michael, T.; GILBERT, Kevin, F.; FERRARA, Marco; SUMMA, Vincenzo; CRESCENZI, Benedetta
Patent: WO2012/40040 A1, 2012 ;
Location in patent: Page/Page column 47-48 ;
WO 2012/040040 A1
反应条件
sodium hydroxide; water T=60°C; 2 h;
参考文献
Schumacher, Richard; Danca, Mihaela Diana; Ma, Jianguo; Herbert, Brian; Nguyen, True Minh; Xie, Wenge; Tehim, Ashok
Patent: US2007/78147 A1, 2007 ;
Location in patent: Page/Page column 67 ;
反应条件
1: 1-hydroxy-2-amino-3-nitrobenzene With sodium hydride in DMF (N,N-dimethyl-formamide) T=0°C; 1.5 h; 2: methyl iodide in DMF (N,N-dimethyl-formamide) T=20°C; 1 h;
参考文献
WO2005/68433 A1, ;
Page/Page column 38 ;
反应条件
ammonium hydroxide in ethanol T=160°C; 6 h;
参考文献
Pytela, Oldrich; Kulhanek, Jiri; Jiraskova, Eva; Nevecna, Tatjana
Collection of Czechoslovak Chemical Communications, 2001 , vol. 66, # 11 p. 1638 - 1658
参考文献
Sumitomo Chemical Company, Limited
Patent: US5466871 A1, 1995 ;
反应条件
in water; ethyl acetate; N,N-dimethyl-formamide
参考文献
Bridger, Gary; Kaller, Al; Harwig, Curtis; Skerlj, Renato; Bogucki, David; Wilson, Trevor R.; Crawford, Jason; McEachern, Ernest J.; Atsma, Bem; Nan, Siqiao; Zhou, Yuanxi; Schols, Dominique; Smith, Christopher D.; Di Fluri, Maria R.
Patent: US2004/19058 A1, 2004 ;
US 20040019058 A1
反应条件
2,4,6-trichlorosulfenamide; potassium tert-butylate in N,N-dimethyl-formamide T=20°C; 0.333333 h;
参考文献
Journal of Organic Chemistry, , vol. 63, # 15 p. 4878 - 4888
反应条件
potassium tert-butylate; 1,1,1-trimethylhydrazinium iodide in dimethyl sulfoxide Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 61, # 9 p. 2934 - 2935
反应条件
1: dichloromethane / 1 h / 20 °C 2: nitric acid; acetic acid / 0.5 h / 0 °C 3: hydrogenchloride / water / 2 h / |Reflux View Scheme
参考文献
Letters in Drug Design and Discovery, , vol. 10, # 4 p. 369 - 373
反应条件
1: nitric acid; acetic acid / 0.5 h / 0 °C 2: hydrogenchloride / water / 2 h / |Reflux View Scheme
参考文献
Letters in Drug Design and Discovery, , vol. 10, # 4 p. 369 - 373
