3,5-二硝基-4-甲基苯甲酸合成路线 （共 42 条）
反应条件
sodium perchromate dihydrate; sulfuric acid
T=20 - 25°C; Cooling with ice;
参考文献
Pound, Graham J.; Pletnev, Alexandre A.; Fang, Xiaomin; Pletneva, Ekaterina V.
Chemical Communications, 2011 , vol. 47, # 20 p. 5714 - 5716
反应条件
1: thionyl chloride / 3 h / Reflux
2: hydrogenchloride; iron / 1,4-dioxane; methanol / Reflux
View Scheme
参考文献
Mochizuki, Akiyoshi; Nagata, Tsutomu; Kanno, Hideyuki; Takano, Daisuke; Kishida, Masamichi; Suzuki, Makoto; Ohta, Toshiharu
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 24 p. 7337 - 7343
反应条件
1: 89 percent / H2SO4 / 37 h / Heating
2: 99 percent / H2 / Pd/C / CH2Cl2; ethanol
3: 78 percent / Na2CO3 / acetone / 4 h / Heating
4: 81 percent / aq. NaOH / tetrahydrofuran / Heating
View Scheme
参考文献
Pickaert, Guillaume; Cesario, Michele; Ziessel, Raymond
Journal of Organic Chemistry, 2004 , vol. 69, # 16 p. 5335 - 5341
反应条件
thionyl chloride
Substitution;
参考文献
Spanggord, Ronald J.; Clizbe, Lane A.
Journal of Labelled Compounds and Radiopharmaceuticals, 1998 , vol. 41, # 7 p. 615 - 621
反应条件
(i) SOCl2, (ii) aq. NaN3; Multistep reaction;
参考文献
Pasini,C. et al.
Gazzetta Chimica Italiana, 1963 , vol. 93, p. 1056 - 1065
反应条件
hydrogenchloride; tin
参考文献
Marckwald
Justus Liebigs Annalen der Chemie, 1893 , vol. 274, p. 357
Full Text Show Details
Claus; Joachim
Justus Liebigs Annalen der Chemie, 1891 , vol. 266, p. 218
反应条件
1: 89 percent / H2SO4 / 37 h / Heating
2: 99 percent / H2 / Pd/C / CH2Cl2; ethanol
3: 74 percent / Na2CO3 / acetone / 4 h / Heating
4: 76 percent / aq. NaOH / tetrahydrofuran / Heating
View Scheme
参考文献
Pickaert, Guillaume; Ziessel, Raymond
Synthesis, 2004 , # 16 p. 2716 - 2726
反应条件
1: 89 percent / H2SO4 / 37 h / Heating
2: 99 percent / H2 / Pd/C / CH2Cl2; ethanol
3: 72 percent / Na2CO3 / acetone / 4 h / Heating
4: 92 percent / aq. NaOH / tetrahydrofuran / Heating
View Scheme
参考文献
Pickaert, Guillaume; Ziessel, Raymond
Synthesis, 2004 , # 16 p. 2716 - 2726
反应条件
amidosulfamic acid in pyridine; water
T=115 - 120°C; 1.5 h;
参考文献
Randall, Jared Lynn; Gibbs, Richard Alan; Bosch, Gregory Kent; Curtis, Michael David; Sun, Li; Nikolaides, Nicholas
Patent: US2004/167194 A1, 2004 ;
Location in patent: Page 20-21 ;
反应条件
1: (NH4)2S / ethanol; water / 10.25 h / 80 °C / Inert atmosphere
2: sulfuric acid; water; sodium nitrite / 5.5 h / 0 - 90 °C / Inert atmosphere
View Scheme
参考文献
Mochizuki, Akiyoshi; Nagata, Tsutomu; Kanno, Hideyuki; Takano, Daisuke; Kishida, Masamichi; Suzuki, Makoto; Ohta, Toshiharu
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 24 p. 7337 - 7343
