1,2,3,4-四氢-9H-吡啶[3,4-B]并吲哚合成路线 （共 42 条）
反应条件
1: With hydrogenchloride in water 2: With potassium hydroxide in water T=20°C; pH=3.5 - 4; 1 h;
参考文献
C4T S.C. A R.L.
Patent: WO2008/148617 A1, 2008 ;
Location in patent: Page/Page column 12 ;
反应条件
Dowex 50W-X4 acidic ion-exchange resin in 1,2-dichloro-ethane T=90°C; Pictet-Spengler cyclisation; Automated synthesizer;
参考文献
IzuMi, Minoru; Kido, Takeshi; Murakami, Miyu; Nakajima, Shuhei; Ganesan
Bioscience, Biotechnology and Biochemistry, 2011 , vol. 75, # 2 p. 391 - 392
反应条件
ammonium formate; palladium dihydroxide in methanol 3.5 h; Heating;
参考文献
Dantale, Shubhada W.; Soederberg, Bjoern C. G.
Tetrahedron, 2003 , vol. 59, # 29 p. 5507 - 5514
反应条件
methyllithium in tetrahydrofuran; diethyl ether 1 h; Ambient temperature;
参考文献
Wender, Paul A.; White, Alan W.
Tetrahedron, 1983 , vol. 39, # 22 p. 3767 - 3776
反应条件
trifluoroacetic acid in acetonitrile T=0°C; 2 h;
参考文献
Singh, Harjit; Sarin, Rakesh
Journal of Chemical Research, Miniprint, 1988 , # 10 p. 2623 - 2640
反应条件
acetic acid in acetonitrile 3.5 h; Heating;
参考文献
Singh, Harjit; Sarin, Rakesh
Journal of Chemical Research, Miniprint, 1988 , # 10 p. 2623 - 2640
反应条件
trifluoroacetic acid in acetonitrile 0.5 h; Ambient temperature;
参考文献
Singh
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1989 , vol. 28, # 10 p. 802 - 805
反应条件
1: HMDS 2: Pd(dba)2; Ph3As; CuI / 1-methyl-pyrrolidin-2-one / 10 h / 50 °C 3: 380 mg / Pd(OAc)2; PPh3; CO / acetonitrile / 15 h / 70 °C / 3040 Torr 4: 91 percent / ammonium formate / Pd(OH)2/C / methanol / 3.5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 59, # 29 p. 5507 - 5514
反应条件
1: Pd(dba)2; Ph3As; CuI / 1-methyl-pyrrolidin-2-one / 10 h / 50 °C 2: 380 mg / Pd(OAc)2; PPh3; CO / acetonitrile / 15 h / 70 °C / 3040 Torr 3: 91 percent / ammonium formate / Pd(OH)2/C / methanol / 3.5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 59, # 29 p. 5507 - 5514
反应条件
1: Pd(PPh3)2Cl2; CuI / 1-methyl-pyrrolidin-2-one / 10 h / 50 °C 2: 380 mg / Pd(OAc)2; PPh3; CO / acetonitrile / 15 h / 70 °C / 3040 Torr 3: 91 percent / ammonium formate / Pd(OH)2/C / methanol / 3.5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 59, # 29 p. 5507 - 5514
