1-(1-甲基-1H-吲哚-2-基)乙酮合成路线 （共 16 条）
反应条件
1: With potassium tert-butylate in methanol T=100°C; 0.5 h; 2: With water in methanol
参考文献
Baxendale, Ian R.; Ley, Steven V.; Mansfield, Andrew C.; Smith, Christopher D.
Angewandte Chemie, International Edition, 2009 , vol. 48, p. 4017 - 4021
Angewandte Chemie, 2009 , vol. 121, p. 4077 - 4081
反应条件
sodium hydroxide; dimethyl sulfate in water
参考文献
Abbott Laboratories
Patent: US4873259 A1, 1989 ;
反应条件
in tetrahydrofuran T=0 - 20°C; 16 h;
参考文献
Lin, Chih-Da; Fang, Jim-Min
Journal of the Chinese Chemical Society (Taipei, Taiwan), 1993 , vol. 40, # 6 p. 571 - 580
反应条件
in diethyl ether 5 h; Heating;
参考文献
Sechi, Mario; Derudas, Massimiliano; Dallocchio, Roberto; Dessi, Alessandro; Bacchi, Alessia; Sannia, Luciano; Carta, Fabrizio; Palomba, Michele; Ragab, Omar; Chan, Carney; Shoemaker, Robert; Sei, Shizuko; Dayam, Raveendra; Neamati, Nouri
Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5298 - 5310
反应条件
1.1: KOH / dimethylsulfoxide / 20 °C 1.2: 93 percent / dimethylsulfoxide / 20 °C 2.1: 92 percent / KOH / H2O / 1 h / Heating 3.1: 55 percent / diethyl ether / 5 h / Heating View Scheme
参考文献
Sechi, Mario; Derudas, Massimiliano; Dallocchio, Roberto; Dessi, Alessandro; Bacchi, Alessia; Sannia, Luciano; Carta, Fabrizio; Palomba, Michele; Ragab, Omar; Chan, Carney; Shoemaker, Robert; Sei, Shizuko; Dayam, Raveendra; Neamati, Nouri
Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5298 - 5310
反应条件
1: 92 percent / KOH / H2O / 1 h / Heating 2: 55 percent / diethyl ether / 5 h / Heating View Scheme
参考文献
Sechi, Mario; Derudas, Massimiliano; Dallocchio, Roberto; Dessi, Alessandro; Bacchi, Alessia; Sannia, Luciano; Carta, Fabrizio; Palomba, Michele; Ragab, Omar; Chan, Carney; Shoemaker, Robert; Sei, Shizuko; Dayam, Raveendra; Neamati, Nouri
Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5298 - 5310
反应条件
1.1: 67 percent / xylene / 0.25 h / Heating 2.1: KOH / dimethylsulfoxide / 20 °C 2.2: 93 percent / dimethylsulfoxide / 20 °C 3.1: 92 percent / KOH / H2O / 1 h / Heating 4.1: 55 percent / diethyl ether / 5 h / Heating View Scheme
参考文献
Sechi, Mario; Derudas, Massimiliano; Dallocchio, Roberto; Dessi, Alessandro; Bacchi, Alessia; Sannia, Luciano; Carta, Fabrizio; Palomba, Michele; Ragab, Omar; Chan, Carney; Shoemaker, Robert; Sei, Shizuko; Dayam, Raveendra; Neamati, Nouri
Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5298 - 5310
反应条件
1.1: 52 percent / MeONa / methanol / 4 h / -15 °C 2.1: 67 percent / xylene / 0.25 h / Heating 3.1: KOH / dimethylsulfoxide / 20 °C 3.2: 93 percent / dimethylsulfoxide / 20 °C 4.1: 92 percent / KOH / H2O / 1 h / Heating 5.1: 55 percent / diethyl ether / 5 h / Heating View Scheme
参考文献
Sechi, Mario; Derudas, Massimiliano; Dallocchio, Roberto; Dessi, Alessandro; Bacchi, Alessia; Sannia, Luciano; Carta, Fabrizio; Palomba, Michele; Ragab, Omar; Chan, Carney; Shoemaker, Robert; Sei, Shizuko; Dayam, Raveendra; Neamati, Nouri
Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5298 - 5310
反应条件
in tetrahydrofuran 1) from -78 deg C to -20 deg C, 1 h; 2) from -78 deg C to room temperature, 1.5 h;
参考文献
Hlasta, Dennis J.; Court, John J.
Tetrahedron Letters, 1989 , vol. 30, # 14 p. 1773 - 1776
反应条件
in diethyl ether T=-40 - 20°C; 16 h;
参考文献
Lin, Chih-Da; Fang, Jim-Min
Journal of the Chinese Chemical Society (Taipei, Taiwan), 1993 , vol. 40, # 6 p. 571 - 580
