1: With diphenyl-N,N-bis-((S,S)-1-naphthalen-2-yl-ethyl)phosphinamine; copper(ll) bromide in diethyl ether
T=-30°C; 3 h;
2: With ammonium chloride in diethyl ether; water
optical yield given as percent eeenantioselective reaction;
(S)-tert-butyl(2-hydroxyphenyl)methylphosphine; copper trifluoromethanesulfonate in hexane; dichloromethane
T=0°C; 0.3 h; Title compound not separated from byproducts;
bis(acetylacetonate)nickel(II); (S,S)-3 bipyridine in hexane; acetonitrile
T=-30°C; 18 h; effect of nickel and ligand concentration, of optical purity of the catalyst, of solvent, of ligand structure and of reaction time on the enantiomeric excess; variation of the substrates and reagents; modification of the catalyst;; Product distribution;
