1-溴-2,3,5,6-四甲基苯合成路线 （共 25 条）
反应条件
hydrogen bromide; [EtNH3][NO3] in water T=30°C; 3 h; Green chemistry; Reagent/catalyst; regioselective reaction;
参考文献
Organic Letters, , vol. 15, # 9 p. 2108 - 2111
反应条件
N-bromosuccinmide; toluene-4-sulfonic acid in methanol 21 h; Ambient temperaturevariation of conditions, other catalysts and reagents, without catalyst, + succinimide (NHS); other polyalkylbenzenes; Product distributionMechanism;
参考文献
Bovonsombat; McNelis
Synthesis, 1993 , # 2 p. 237 - 241
反应条件
copper(I) oxide; sodium hydroxide; copper bronze in water T=260°C; 3 h; steel bomb;
参考文献
Koutek, Bohumir; Musil, Lubomir; Velek, Jiri; Lycka, Antonin; Snobl, Dobroslav; et al.
Collection of Czechoslovak Chemical Communications, 1981 , vol. 46, # 10 p. 2540 - 2556
反应条件
1: magnesium / tetrahydrofuran / 14 h 2: N-bromosuccinmide / acetonitrile / 8 h / 0 - 20 °C View Scheme
参考文献
Mandal, Susovan; Parida, Keshaba Nanda; Samanta, Subhas; Moorthy, Jarugu Narasimha
Journal of Organic Chemistry, 2011 , vol. 76, # 18 p. 7406 - 7414
反应条件
1: magnesium; diethyl ether; benzene / Einleiten von Kohlendioxid in die Reaktionsloesung View Scheme
参考文献
Weizmann
Journal of the American Chemical Society, 1948 , vol. 70, p. 2342
参考文献
Smith; Moyle
Journal of the American Chemical Society, 1933 , vol. 55, p. 1676,1681
参考文献
Jacobsen
Chemische Berichte, 1887 , vol. 20, p. 2837
反应条件
1: 80 percent / pyridine; potassium permanganate / H2O / 13 h / Heating 2: thionyl chloride; N,N-dimethylformamide / 8 h / Heating 3: 1 h / Heating 4: 32 percent / copper bronze / dimethylformamide / 3.5 h / 150 °C View Scheme
参考文献
Holy, Petr; Sehnal, Petr; Tichy, Milos; Zavada, Jiri; Cisarova, Ivana
Tetrahedron Asymmetry, 2004 , vol. 15, # 23 p. 3805 - 3810
反应条件
magnesium in tetrahydrofuran 14 h;
参考文献
Mandal, Susovan; Parida, Keshaba Nanda; Samanta, Subhas; Moorthy, Jarugu Narasimha
Journal of Organic Chemistry, 2011 , vol. 76, # 18 p. 7406 - 7414
反应条件
diethyl ether; magnesium; benzene Einleiten von Kohlendioxid in die Reaktionsloesung;
参考文献
Fuson; Kelton
Journal of the American Chemical Society, 1941 , vol. 63, p. 1500
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Coops et al.
Recueil des Travaux Chimiques des Pays-Bas, 1940 , vol. 59, p. 1109,1111
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Weizmann
Journal of the American Chemical Society, 1948 , vol. 70, p. 2342
