5-氯-2-（甲硫基）苯胺合成路线 （共 6 条）
反应条件
1: 2-amino-4-chlorobenzenethiol With potassium tert-butylate in ethanol T=0°C; 1.25 h; 2: methyl iodide in ethanol T=0 - 20°C; 2.5 h; Further stages.;
参考文献
Hodson, Stephen J.; Bishop, Michael J.; Speake, Jason D.; Navas III, Frank; Garrison, Deanna T.; Bigham, Eric C.; Saussy Jr., David L.; Liacos, James A.; Irving, Paul E.; Jeffrey Gobel; Sherman, Bryan W.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 11 p. 2229 - 2239
反应条件
1.1: 92 percent / NaOH / ethane-1,2-diol / 2.5 h / Heating 2.1: potassium t-butoxide / ethanol / 1.25 h / 0 °C 2.2: 61 percent / ethanol / 2.5 h / 0 - 20 °C View Scheme
参考文献
Hodson, Stephen J.; Bishop, Michael J.; Speake, Jason D.; Navas III, Frank; Garrison, Deanna T.; Bigham, Eric C.; Saussy Jr., David L.; Liacos, James A.; Irving, Paul E.; Jeffrey Gobel; Sherman, Bryan W.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 11 p. 2229 - 2239
反应条件
hydrogenchloride; iron; copper dichloride T=60 - 70°C;
参考文献
Goldkamp,A.H.
Journal of Organic Chemistry, 1969 , vol. 34, # 6 p. 1780 - 1785
反应条件
1: KOH 2: SnCl2, aq. HCl View Scheme
参考文献
Goldkamp,A.H.
Journal of Organic Chemistry, 1969 , vol. 34, # 6 p. 1780 - 1785
反应条件
trifluorormethanesulfonic acid; trifluoroacetic acid T=25°C; 4 h; Title compound not separated from byproducts;
参考文献
Takeuchi, Hiroshi; Itou, Kazuaki; Murai, Hirotaka; Koyama, Kikuhiko
Journal of Chemical Research, Miniprint, 1991 , # 12 p. 3156 - 3188
反应条件
1: NaOH-solution 2: aqueous-methanolic copper (II)-chloride; iron; concentrated hydrochloric acid / 60 - 70 °C View Scheme
参考文献
Brand; Groebe
Journal fuer Praktische Chemie (Leipzig), 1924 , vol. <2> 108, p. 12
