1: 86 percent / potassium carbonate / dimethylformamide / 3 h / Heating 2: 91 percent / ammonium chloride / methanol / 4 h / Heating 3: 94 percent / 1.) n-butyl lithium / hexane; diethyl ether / 1.) -78 deg C, 10 min, 2.) -78 deg C to room temperature, 3 h 4: 93 percent / potassium hydroxide / ethanol / 4 h 5: 87 percent / conc. HCl / dioxane; methanol / 1.5 h / Ambient temperature 6: 92 percent / 30percent H2O2, 5percent NaOH / dioxane; methanol / 3 h / Ambient temperature 7: 1.) boron trifluoride etherate, 2.) sodium borohydride / 1.) benzene, 20 min, 2.) THF, room temperature, 2 h 8: 66 percent / hydrogen / 10percent Pd/C / methanol 9: 77 percent / boron trifluoride etherate / acetic acid / 0.25 h / 5 °C 10: 66 percent / diisopropylethylamine / CH2Cl2 / 3 h / Ambient temperature 11: 91 percent / 1N NaOH / methanol / 1 h / Ambient temperature 12: 95 percent / manganese dioxide / CH2Cl2 / 0.5 h 13: 94 percent / sodium hydroxide / ethanol / 4 h 14: 96 percent / 30percent H2O2, 5percent NaOH / methanol / 4 h / Ambient temperature 15: 19 percent / conc. HCl / methanol / 0.25 h / 70 °C View Scheme

KF in N,N-dimethyl-formamide

potassium fluoride in N,N-dimethyl-formamide T=105°C; 2 h;

caesium carbonate in DMF (N,N-dimethyl-formamide) T=110°C; 20 h;

potassium carbonate in N,N-dimethyl-formamide T=100°C; 3 h;

potassium hydroxide; dimethyl sulfate

暂无反应条件数据

1: aqueous KOH-solution; methylene sulfate 2: acetone; aqueous potassium permanganate solution View Scheme

1.1: 71 percent / copper(II) chloride / dimethylformamide / 2 h / Heating 2.1: pyridine / 55 °C 2.2: 94 percent / aniline; piperidine / 20 °C View Scheme

1.1: 63 percent / K2CO3 / dimethylformamide / 3 h / 100 °C 2.1: toluene / 3.5 h / Heating 3.1: n-BuLi / diethyl ether; hexane / -78 °C 3.2: diethyl ether; hexane / -78 - 20 °C 4.1: H2O2 / methanol; H2O / 0.25 h 4.2: 0.91 g / aq. HCl / 100 °C View Scheme