5-溴-3, 4-二羟苯甲醛合成路线 （共 23 条）
反应条件
1: With boron tribromide in dichloromethane T=0 - 20°C; 2.83333 h; 2: With methanol in dichloromethane T=0°C;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/14580 A1, 2006 ;
Location in patent: Page/Page column 50 ;
反应条件
bromine in acetic acid
参考文献
Bailey, Karl L.; Molinski, Tadeusz F.
Tetrahedron Letters, 2002 , vol. 43, # 52 p. 9657 - 9661
反应条件
sulfuric acid; dihydrogen peroxide; bromine in dichloromethane T=45°C; 2 h; Further byproducts given;
参考文献
Afanas'eva, V. L.; Lyubeshkin, A. V.; Kovaleva, S. S.; Bagreeva, M. R.; Anisimova, O. S.; Glushkov, R. G.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 11 p. 805 - 809
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 11 p. 1367 - 1371
反应条件
1: 90 percent / Br2 / acetic acid / 3 h / 20 °C 2: 98 percent / AlCl3; pyridine / CH2Cl2 / 24 h / 40 °C View Scheme
参考文献
Organic letters, , vol. 3, # 13 p. 2061 - 2064
反应条件
copper dichloride in N,N-dimethyl-formamide 2 h; Heating;
参考文献
Russell, Wendy R.; Burkitt, Mark J.; Scobbie, Lorraine; Chesson, Andrew
Bioorganic Chemistry, 2003 , vol. 31, # 3 p. 206 - 215
反应条件
bromine; acetic acid 6 h; Heating;
参考文献
Shoeib, Nagwa A.; Bibby, Michael C.; Blunden, Gerald; Linley, Peter A.; Swaine, David J.; Wheelhouse, Richard T.; Wright, Colin W.
Journal of Natural Products, 2004 , vol. 67, # 9 p. 1445 - 1449
反应条件
1: K2CO3 / dimethylformamide / 20 °C 2: pTsOH 3: 99 percent / nBuLi; CuBr*Me2S / benzene; diethyl ether 4: 76 percent / Na / butan-2-ol / 80 °C 5: 19 percent / SeO2; SiO2; tBuOOH / microwave irradiation View Scheme
参考文献
Odejinmi, Sina I.; Wiemer, David F.
Tetrahedron Letters, 2005 , vol. 46, # 22 p. 3871 - 3874
反应条件
1: 5-bromo-3,4-dihydroxybenzaldehyde With lithium carbonate in N,N-dimethyl-formamide T=45°C; 1 h; 2: methyl iodide in N,N-dimethyl-formamide T=45°C;
参考文献
Sloman, David L.; Mitasev, Branko; Scully, Stephen S.; Beutler, John A.; Porco Jr., John A.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 11 p. 2511 - 2515
反应条件
in 1,4-dioxane; diethyl ether
参考文献
Anhoury; Crooy; De Neys; Eliaers
Bulletin des Societes Chimiques Belges, 1974 , vol. 83, # 3-4 p. 117 - 124
反应条件
1: 85 percent / KF / dimethylformamide / 2 h / 105 °C 2: 1.) n-BuLi; 2.) nitrobenzene / 1.) THF, hexane, -75 deg C, 50 min.; 2.) -75 deg C, 4h, -> room temp. View Scheme
参考文献
Sinhababu, Achintya K.; Borchardt, Ronald T.
Journal of Organic Chemistry, 1983 , vol. 48, # 12 p. 1941 - 1944
